Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
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DOI: 10.1021/acs.jmedchem.1c00918
Abstract: The bacterial DNA sliding clamp (SC), or replication processivity factor, is a promising target for the development of novel antibiotics. We report a structure-activity relationship study of a new series of peptides interacting within the… read more here.
Keywords: sliding clamp; based optimization; optimization short; structure based ... See more keywords