P01.24 The selective HDAC6 inhibitor ITF3756 increases the differentiation to central memory T cells with reduced exhaustion phenotype
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-itoc7.36
Abstract: Background Central memory T cells show superior persistence and antitumor immunity compared to effector memory and effector T cells. T effector cells respond quickly to tumors, but they are terminally differentiated and undergo apoptosis upon… read more here.
Keywords: expression; phenotype; memory; memory cells ... See more keywords
Abstract 6245: Selective HDAC6 inhibition by ITF3756 modifies the landscape of gene and protein expression in human monocytes: Possible identification of a specific biomarker signature
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6245
Abstract: Histone deacetylase 6 (HDAC6) modulates tumor immunogenicity through several pathways, such as the control of PD-L1 expression on tumor and on lymphoid cells. Thus, HDAC6 is a potential pharmacological target for cancer treatment. In humans,… read more here.
Keywords: signature; itf3756; identification; expression ... See more keywords