Acquired resistance to temsirolimus is associated with integrin α7 driven chemotactic activity of renal cell carcinoma in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.24650
Abstract: The mechanistic target of the rapamycin (mTOR) inhibitor, temsirolimus, has significantly improved the outcome of patients with renal cell carcinoma (RCC). However, development of temsirolimus-resistance limits its effect and metastatic progression subsequently recurs. Since integrin… read more here.
Keywords: renal cell; itga7; cell carcinoma; resistance ... See more keywords
ITGA7 functions as a tumor suppressor and regulates migration and invasion in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Management and Research"
DOI: 10.2147/cmar.s160379
Abstract: Background Breast cancer is the most common malignancy in women and the underlying mechanism of breast cancer cell metastasis is still far from uncover. Integrin subunit alpha 7 (ITGA7) is a functioning protein. It has… read more here.
Keywords: invasion; itga7; breast cancer; migration ... See more keywords
Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma
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DOI: 10.3390/cancers12020363
Abstract: Acute myeloid leukemia (AML) with granulocytic sarcoma (GS) is characterized by poor prognosis; however, its underlying mechanism is unclear. Bone marrow samples from 64 AML patients (9 with GS and 55 without GS) together with… read more here.
Keywords: integrin extracellular; granulocytic sarcoma; itga7; myeloid leukemia ... See more keywords
Cyanidin-3-O-Glucoside Rescues Zearalenone-Induced Apoptosis via the ITGA7-PI3K-AKT Signaling Pathway in Porcine Ovarian Granulosa Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054441
Abstract: Zearalenone (ZEN) is an important secondary metabolite of Fusarium fungi, exposure to which can cause reproductive disorders through its effects on ovarian granulosa cells (GCs) in many mammals, especially in pigs. This study aimed to… read more here.
Keywords: pi3k akt; c3g; itga7; apoptosis ... See more keywords