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   Articles with "itgb1" as a keyword



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Plating human iPSC lines on micropatterned substrates reveals role for ITGB1 nsSNV in endoderm formation.

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recommendations! Published in 2021 at "Stem cell reports"

DOI: 10.1016/j.stemcr.2021.09.017

Abstract: Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors is a powerful tool for uncovering the relationship between genetic variants and cellular behavior. We previously identified rare, deleterious non-synonymous single nucleotide… read more here.

Keywords: plating human; itgb1; ipsc lines; cell ... See more keywords
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Inhibition of ITGB1 enhance the anti-tumor effect of cetuximab in colorectal cancer cell

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recommendations! Published in 2020 at "Medicine"

DOI: 10.1097/md.0000000000020944

Abstract: Supplemental Digital Content is available in the text Abstract Background: Colorectal cancer is the second commonly seen cancer around the world and accounts for 13% of all human cancers. Among them, 25% of all case… read more here.

Keywords: cancer; effect; colorectal cancer; inhibition ... See more keywords
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Integrin Beta 1 Promotes Glioma Cell Proliferation by Negatively Regulating the Notch Pathway

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recommendations! Published in 2020 at "Journal of Oncology"

DOI: 10.1155/2020/8297017

Abstract: In this study, genes associated with the Notch signaling pathway in gliomas were analyzed using bioinformatics and in vitro experiments. The dataset GSE22772 was downloaded from the Gene-Cloud of Biotechnology Information database. Differentially expressed genes… read more here.

Keywords: cell proliferation; itgb1; expression; glioma ... See more keywords
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Abstract 4022: Integrin β1 regulates doxorubicin resistance in breast cancer via FAK-mediated activation of ERK1 pathway

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recommendations! Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-4022

Abstract: Introduction: Emergence of chemoresistance is one of the major concerns in cancer management. Development of chemoresistance is associated with several genotypical and phenotypical changes in cancer cells, making them less vulnerable to chemotherapeutic assaults. Integrins… read more here.

Keywords: itgb1; chemoresistance; breast cancer; expression ... See more keywords
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ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells.

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recommendations! Published in 2022 at "Die Pharmazie"

DOI: 10.1691/ph.2022.2351

Abstract: Cardiomyocyte autophagy is closely related to myocardial infarction and hypertrophy. To study the molecular mechanism of autophagy is helpful for the prevention and treatment of these diseases. As a cell surface receptor, the function of… read more here.

Keywords: itgb1; h9c2 cells; mtorc2 akt; autophagy ... See more keywords
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High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.17650

Abstract: Increasing evidence supports that microRNA (miRNA)-mediated gene regulation plays a significant functional role in cancer progression. To investigate the expression and clinical significance of ITGB1 in non small cell lung cancer (NSCLC), the expression levels… read more here.

Keywords: itgb1; expression; mir 493; non small ... See more keywords
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ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer

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recommendations! Published in 2023 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2023.1115510

Abstract: Diffuse type gastric cancer was identified with relatively worse prognosis than other Lauren’s histological classification. Integrin β1 (ITGB1) was a member of integrin family which played a markedly important role in tumorigenesis and progression. However,… read more here.

Keywords: itgb1; expression; gastric cancer; worse prognosis ... See more keywords
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Study on the mechanism of multi-AGC kinase AT13148 on Notch signaling pathway in glioblastoma

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recommendations! Published in 2021 at "Archives of Medical Science"

DOI: 10.5114/aoms/135083

Abstract: Introduction Glioblastoma is the most malignant astrocytoma, and its therapeutic effect is not ideal. Notch signaling pathway plays an important role in tumor proliferation and invasion. Whether small molecule drug AT13148 can affect glioblastoma by… read more here.

Keywords: glioblastoma; notch signaling; signaling pathway; itgb1 ... See more keywords

ITGB1 enhances the Radioresistance of human Non-small Cell Lung Cancer Cells by modulating the DNA damage response and YAP1-induced Epithelial-mesenchymal Transition

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recommendations! Published in 2021 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.52319

Abstract: Objectives: Radiotherapy has played a limited role in the treatment of non-small cell lung cancer (NSCLC) due to the risk of tumour radioresistance. We previously established the radioresistant non-small cell lung cancer (NSCLC) cell line… read more here.

Keywords: yap1; itgb1; radioresistance; non small ... See more keywords