Piezo1/ITGB1 Synergizes With Ca2+/YAP Signaling to Propel Bladder Carcinoma Progression via a Stiffness‐Dependent Positive Feedback Loop
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.71059
Abstract: Emerging evidence implicates mechanotransduction pathways in modulating bladder carcinoma (BLCA) pathogenesis. However, the crosstalk between Piezo1 and integrin β1 (ITGB1) in extracellular matrix (ECM) stiffness‐driven tumorigenesis remains a critical knowledge gap. This study systematically investigates… read more here.
Keywords: bladder carcinoma; piezo1 itgb1; itgb1;
Exosomes enriched by miR-429-3p derived from ITGB1 modified Telocytes alleviates hypoxia-induced pulmonary arterial hypertension through regulating Rac1 expression
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-024-09879-0
Abstract: Recent studies have emphasized the critical role of Telocytes (TCs)-derived exosomes in organ tissue injury and repair. Our previous research showed a significant increase in ITGB1 within TCs. Pulmonary Arterial Hypertension (PAH) is marked by… read more here.
Keywords: exo itgb1; itgb1; mir 429; itgb1 modified ... See more keywords
Plating human iPSC lines on micropatterned substrates reveals role for ITGB1 nsSNV in endoderm formation.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell reports"
DOI: 10.1016/j.stemcr.2021.09.017
Abstract: Quantitative analysis of human induced pluripotent stem cell (iPSC) lines from healthy donors is a powerful tool for uncovering the relationship between genetic variants and cellular behavior. We previously identified rare, deleterious non-synonymous single nucleotide… read more here.
Keywords: plating human; itgb1; ipsc lines; cell ... See more keywords
Inhibition of ITGB1 enhance the anti-tumor effect of cetuximab in colorectal cancer cell
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000020944
Abstract: Supplemental Digital Content is available in the text Abstract Background: Colorectal cancer is the second commonly seen cancer around the world and accounts for 13% of all human cancers. Among them, 25% of all case… read more here.
Keywords: cancer; effect; colorectal cancer; inhibition ... See more keywords
Integrin Beta 1 Promotes Glioma Cell Proliferation by Negatively Regulating the Notch Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oncology"
DOI: 10.1155/2020/8297017
Abstract: In this study, genes associated with the Notch signaling pathway in gliomas were analyzed using bioinformatics and in vitro experiments. The dataset GSE22772 was downloaded from the Gene-Cloud of Biotechnology Information database. Differentially expressed genes… read more here.
Keywords: cell proliferation; itgb1; expression; glioma ... See more keywords
Abstract 4022: Integrin β1 regulates doxorubicin resistance in breast cancer via FAK-mediated activation of ERK1 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4022
Abstract: Introduction: Emergence of chemoresistance is one of the major concerns in cancer management. Development of chemoresistance is associated with several genotypical and phenotypical changes in cancer cells, making them less vulnerable to chemotherapeutic assaults. Integrins… read more here.
Keywords: itgb1; chemoresistance; breast cancer; expression ... See more keywords
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis.
Sign Up to like & getrecommendations! Published in 2024 at "International heart journal"
DOI: 10.1536/ihj.24-207
Abstract: Diabetic cardiopathy is a common clinical complication of diabetes and is one of the main causes of mortality in type 2 diabetes mellitus patients. In this study, we examined the effect and mechanism of integrin… read more here.
Keywords: high glucose; itgb1; glucose; glucose induced ... See more keywords
ITGB1 Suppresses Autophagy Through Inhibiting The mTORC2/AKT Signaling Pathway In H9C2 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Die Pharmazie"
DOI: 10.1691/ph.2022.2351
Abstract: Cardiomyocyte autophagy is closely related to myocardial infarction and hypertrophy. To study the molecular mechanism of autophagy is helpful for the prevention and treatment of these diseases. As a cell surface receptor, the function of… read more here.
Keywords: itgb1; h9c2 cells; mtorc2 akt; autophagy ... See more keywords
High expression of miR-493-5p positively correlates with clinical prognosis of non small cell lung cancer by targeting oncogene ITGB1
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.17650
Abstract: Increasing evidence supports that microRNA (miRNA)-mediated gene regulation plays a significant functional role in cancer progression. To investigate the expression and clinical significance of ITGB1 in non small cell lung cancer (NSCLC), the expression levels… read more here.
Keywords: itgb1; expression; mir 493; non small ... See more keywords
ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1115510
Abstract: Diffuse type gastric cancer was identified with relatively worse prognosis than other Lauren’s histological classification. Integrin β1 (ITGB1) was a member of integrin family which played a markedly important role in tumorigenesis and progression. However,… read more here.
Keywords: itgb1; expression; gastric cancer; worse prognosis ... See more keywords
Study on the mechanism of multi-AGC kinase AT13148 on Notch signaling pathway in glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Medical Science"
DOI: 10.5114/aoms/135083
Abstract: Introduction Glioblastoma is the most malignant astrocytoma, and its therapeutic effect is not ideal. Notch signaling pathway plays an important role in tumor proliferation and invasion. Whether small molecule drug AT13148 can affect glioblastoma by… read more here.
Keywords: glioblastoma; notch signaling; signaling pathway; itgb1 ... See more keywords