Integrin β5 interacts with G3BP1 through activating FAK/Src signaling pathway to promote gastric carcinogenesis
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DOI: 10.1038/s41598-025-14067-z
Abstract: Previous studies demonstrated that integrin β5 (ITGB5) play an important role in the occurrence and development of various malignant tumors. However, its functional mechanism in gastric cancer (GC) remains obscure. We detected that ITGB5 was… read more here.
Keywords: src; itgb5; fak src; interacts g3bp1 ... See more keywords
ITGB5-mediated biomechanical regulation in pancreatic ductal adenocarcinoma stroma impacts tumor progression and prognosis
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DOI: 10.1186/s12967-025-07119-5
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by stromal remodelling andstiffening, a process involving extracellular matrix (ECM) depositionand cross-linking, which forms a dense physical barrier that limits the penetration of chemotherapeutic agents and restricts immune cell-mediated… read more here.
Keywords: cancer; itgb5; prognosis; stroma ... See more keywords
Expression and Pathogenic Analysis of Integrin Family Genes in Systemic Sclerosis
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DOI: 10.3389/fmed.2021.674523
Abstract: Objectives: Emerging evidence shows that integrin members are involved in inflammation and fibrosis in systemic sclerosis (SSc). This study aimed at evaluating the expression of integrin family genes in the skin tissue from SSc patients… read more here.
Keywords: integrin family; itgb5; analysis; expression ... See more keywords