Tumor-associated hemorrhage in patients with vestibular schwannoma
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-018-3588-7
Abstract: ObjectIntratumoral hemorrhage (ITH) associated with vestibular schwannomas (VS) is very rare. We retrospectively analyzed VS patients presenting with ITH in our department to further gain a better understanding of this uncommon clinical presentation.MethodsWe treated seven… read more here.
Keywords: hemorrhage patients; patients vestibular; tumor associated; hemorrhage ... See more keywords
Impact of Cancer Evolution on Immune Surveillance and Checkpoint Inhibitor Response.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2021.02.013
Abstract: Intratumour heterogeneity (ITH) is pervasive across all cancers studied and may provide the evolving tumour multiple routes to escape immune surveillance. Immune checkpoint inhibitors (CPIs) are rapidly becoming standard of care for many cancers. Here,… read more here.
Keywords: immune surveillance; response; surveillance; checkpoint inhibitor ... See more keywords
Paradoxical roles of mutational load as a determinant of anticancer immunity
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-019-0282-5
Abstract: Immune-checkpoint inhibitors (ICIs) have reshaped oncology practice, but continued research is required to understand why only a minority of patients have durable responses and to better identify this subgroup. A high tumour mutational burden (TMB)… read more here.
Keywords: cell; anticancer immunity; effect; tmb ... See more keywords
Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx169
Abstract: Intratumoral heterogeneity (ITH) has increasingly being described for multiple cancers as the root cause of therapy resistance. Recent studies have started to explore the scope of ITH in glioblastoma (GBM), a highly aggressive and fatal… read more here.
Keywords: glioblastoma; treatment; intratumoral heterogeneity; resistance ... See more keywords
Abstract 97: Multiregional profiling revealed intra-tumor transcriptomic heterogeneity associated with the prognosis in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-97
Abstract: Introduction: Intratumor heterogeneity (ITH) describes the distinct tumor cell populations and microenvironments within the same tumor, which may profoundly impact cancer evolution and clinical outcomes. Non-small cell lung cancer (NSCLC) is not only a genetically… read more here.
Keywords: prognosis; signature; ith; expression ... See more keywords
The prognostic effect of HER2 heterogeneity and YAP1 expression in HER2 positive breast cancer patients: a retrospective study.
Sign Up to like & getrecommendations! Published in 2022 at "Gland surgery"
DOI: 10.21037/gs-22-52
Abstract: Background This study sought to estimate the prognostic effect of intratumoral heterogeneity (ITH) and Yes-associated protein 1 (YAP1) intensity in human epidermal growth factor receptor 2 (HER2) positive breast cancer patients. We also investigated individualized… read more here.
Keywords: ith; her2; cancer patients; breast cancer ... See more keywords
Intratumor Heterogeneity as a Prognostic Factor in Solid Tumors: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.744064
Abstract: Background The landscape of intratumor heterogeneity (ITH) is present from the tumor evolution. ITH is a promising clinical indicator, but the association between ITH and prognosis remains controversial. Therefore, a meta-analysis was performed to explore… read more here.
Keywords: solid tumors; prognostic factor; intratumor heterogeneity; ith ... See more keywords
A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11030391
Abstract: Intratumor genetic heterogeneity (ITH) is the main obstacle to effective cancer treatment and a major mechanism of drug resistance. It results from the continuous evolution of different clones of a tumor over time. However, the… read more here.
Keywords: genetic heterogeneity; heterogeneity; ith; cancer ... See more keywords
Intratumoral Genetic Heterogeneity in Papillary Thyroid Cancer: Occurrence and Clinical Significance
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12020383
Abstract: Intratumoral heterogeneity (ITH) refers to a subclonal genetic diversity observed within a tumor. ITH is the consequence of genetic instability and accumulation of genetic alterations, two mechanisms involved in the progression from an early tumor… read more here.
Keywords: papillary thyroid; heterogeneity; ith; significance ... See more keywords
Chromosomal Instability, Selection and Competition: Factors That Shape the Level of Karyotype Intra-Tumor Heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14204986
Abstract: Simple Summary Each cancer consists of billions of cells. These cells are far from identical; hence, the population of cells that constitute a tumor is heterogeneous. A salient property that varies between cells in a… read more here.
Keywords: heterogeneity; shape level; karyotype; ith ... See more keywords
HER2 Intratumoral Heterogeneity in Breast Cancer, an Evolving Concept
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15102664
Abstract: Simple Summary HER2 intratumoral heterogeneity (ITH) is a well-known phenomenon in breast cancer, defined as the coexistence of subpopulations of tumor cells with different HER2 gene or protein expression within a tumor. HER2 ITH has… read more here.
Keywords: breast cancer; her2; anti her2; ith ... See more keywords