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Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor ONO-7790500 Prevents Acute Gvhd in Mouse BMT Model

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Published in 2020 at "Biology of Blood and Marrow Transplantation"

DOI: 10.1016/j.bbmt.2019.12.026

Abstract: Introduction and Objectives Graft-versus-host disease (GVHD) triggered by activated donor graft cells still remains a major complication and course of non-relapse mortality after HSCT. Interleukin-2-inducible T-cell kinase (ITK) is a TEC family cytoplasmic tyrosine kinase… read more here.

Keywords: itksi; cd4 cells; bmt; model ... See more keywords