Genetic variants in toll‐like receptor 4 are associated with lack of steroid‐responsiveness in pediatric ITP patients
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.25716
Abstract: Although the most common front‐line therapies for immune thrombocytopenia (ITP) have been in use for decades, it is still not possible to predict an individual patient's clinical course and response to therapy. Patients are managed… read more here.
Keywords: toll like; response; itp patients; like receptor ... See more keywords
Evaluation of IVIG response in relation to Th1/Th2 cytokines in pediatricm immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.05.014
Abstract: Immune thrombocytopenia (ITP) is a common immune-mediated bleeding disorder in children, and intravenous immunoglobulin (IVIG) is widely used as the initial therapy of ITP. Effective predictive factors of response to IVIG in ITP are important… read more here.
Keywords: itp patients; ivig response; immune thrombocytopenia; ivig ... See more keywords
Increased ADAM10 expression in patients with immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.12.004
Abstract: ABSTRACT Immune thrombocytopenia (ITP) is an autoimmune disease, which is characterized by abnormal of T immunity. A disintegrin and metalloproteinase (ADAM) 10, a member of proteinase family, has been demonstrated to regulate T cell proliferation… read more here.
Keywords: itp patients; level; active itp; expression ... See more keywords
Assessment of plasmablast cells in immune thrombocytopenic purpura in children
Sign Up to like & getrecommendations! Published in 2022 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2021.2024928
Abstract: Abstract Primary immune thrombocytopenic purpura (ITP) is an autoimmune disorder with platelet destruction due to B- and T-cell dysregulation and antiplatelet autoantibodies production. Flow cytometry can be used to further characterize the B- and T-cell… read more here.
Keywords: immune thrombocytopenic; itp patients; thrombocytopenic purpura; plasmablast cells ... See more keywords
Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia.
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DOI: 10.1080/09537104.2022.2144194
Abstract: The association between T-cell large granular lymphocytes (T-LGL) and ITP is uncertain. The aims of this study were to determine the prevalence of T-LGL in patients with ITP and to describe its association with ITP… read more here.
Keywords: patients itp; itp patients; itp; lgl ... See more keywords
Immune dysregulation in primary immune thrombocytopenia patients
Sign Up to like & getrecommendations! Published in 2018 at "Hematology"
DOI: 10.1080/10245332.2018.1435021
Abstract: ABSTRACT Objectives: To explore the immunological abnormalities in patients with primary immune thrombocytopenia (ITP), and analyze its relationship with treatment. Methods: Proportion of different immune cell subsets were detected in the peripheral blood of 124… read more here.
Keywords: treatment; group; itp patients; primary immune ... See more keywords
Blockage of CD72 reduces B cell proliferation in immune thrombocytopenic purpura, involving interleukin 1 and macrophage migration inhibitory factor secretion
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2140992
Abstract: ABSTRACT Aim This study aims to explore the expression and role of CD72 in B lymphocytes in immune thrombocytopenic purpura (ITP). Methods The expression level of CD72 in B lymphocytes was detected by flow cytometry… read more here.
Keywords: antibody; itp patients; cell proliferation; cd72 ... See more keywords
PD-1/PD-L1 pathway activation restores the imbalance of Th1/Th2 and treg/Th17 cells subtypes in immune thrombocytopenic purpura patients
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000017608
Abstract: Abstract This study aims to investigate the changes of cytokines and the effect of programmed death ligand 1 (PD-L1) signaling pathway on T cell function in patients with immune thrombocytopenic purpura (ITP). Totally, 40 untreated… read more here.
Keywords: thrombocytopenic purpura; imbalance th1; immune thrombocytopenic; th1 th2 ... See more keywords
Decreased function of Fas and variations of the perforin gene in adult patients with primary immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14248
Abstract: A defective switching off of the immune response is involved in several autoimmune diseases. This switching off involves Fas‐mediated apoptosis, perforin‐mediated fratricide of activated lymphocytes, and the suppressive activity of regulatory T (Treg) cells. These… read more here.
Keywords: thrombocytopenia; itp patients; primary immune; immune thrombocytopenia ... See more keywords
Humoral response to mRNA‐based COVID‐19 vaccine in patients with immune thrombocytopenia
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18578
Abstract: Data for COVID‐19 vaccine response in patients with immune thrombocytopenia (ITP) are very limited. In a study of 28 patients with ITP, anti‐severe acute respiratory syndrome coronavirus 2 spike antibody titres were measured after vaccination.… read more here.
Keywords: patients immune; immune thrombocytopenia; itp patients; covid vaccine ... See more keywords
Plasma long noncoding RNAs lncDC and THRIL as potential diagnostic markers of adult primary immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of laboratory hematology"
DOI: 10.1111/ijlh.14041
Abstract: INTRODUCTION Immune thrombocytopenia (ITP) is a common acquired hemorrhagic disease without "gold standard" for the diagnosis, long non-coding RNA (lncRNAs) can participate in regulating gene expression through various mechanisms and may play a role in… read more here.
Keywords: immune thrombocytopenia; itp patients; lncdc thril; adult primary ... See more keywords