Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia
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DOI: 10.1007/s00280-018-3732-3
Abstract: PurposeToxicity of 6-Mercaptopurine (6MP) is related to single nucleotide polymorphism (SNP) in genes coding for metabolizing enzymes, with TPMT analysis being recommended prior to maintenance therapy. However, ITPA and NUDT15 polymorphisms appear more important in… read more here.
Keywords: tpmt itpa; itpa; itpa nudt15; risk snp ... See more keywords
Distribution of Genetic Polymorphisms of Genes Implicated in Thiopurine Drugs Metabolism
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DOI: 10.1097/ftd.0000000000000548
Abstract: Abstract: Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are crucial enzymes involved in the metabolism of thiopurine drugs. Significant interethnic variation in the expression of TPMT and ITPA is caused by single nucleotide polymorphisms of… read more here.
Keywords: itpa; polymorphisms genes; thiopurine; tpmt ... See more keywords