Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia
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DOI: 10.1007/s00280-018-3732-3
Abstract: PurposeToxicity of 6-Mercaptopurine (6MP) is related to single nucleotide polymorphism (SNP) in genes coding for metabolizing enzymes, with TPMT analysis being recommended prior to maintenance therapy. However, ITPA and NUDT15 polymorphisms appear more important in… read more here.
Keywords: tpmt itpa; itpa; itpa nudt15; risk snp ... See more keywords