Loss of Arid1a and Pten in pancreatic ductal cells induces intraductal tubulopapillary neoplasm via the YAP/TAZ pathway.
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DOI: 10.1053/j.gastro.2022.04.020
Abstract: KGROUND AND AIMS Pancreatic ductal adenocarcinoma (PDAC) arises from several types of premalignant lesions, including intraductal tubulopapillary neoplasm (ITPN); however, the molecular pathogenesis of ITPN remains unknown. METHODS We performed studies with Hnf1b-CreERT2; Ptenf/f; Arid1af/f… read more here.
Keywords: arid1a; ductal cells; itpn; taz pathway ... See more keywords
Integrative analysis reveals early and distinct genetic and epigenetic changes in intraductal papillary and tubulopapillary cholangiocarcinogenesis
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DOI: 10.1136/gutjnl-2020-322983
Abstract: Objective A detailed understanding of the molecular alterations in different forms of cholangiocarcinogenesis is crucial for a better understanding of cholangiocarcinoma (CCA) and may pave the way to early diagnosis and better treatment options. Design… read more here.
Keywords: intraductal papillary; ipnb itpn; itpn; invasive cca ... See more keywords