A gain‐of‐function mutation in the ITPR1 gating domain causes male infertility in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30783
Abstract: Inositol 1,4,5‐trisphosphate receptor 1 (ITPR1) is an intracellular Ca2+ release channel critical for numerous cellular processes. Despite its ubiquitous physiological significance, ITPR1 mutations have thus far been linked to primarily movement disorders. Surprisingly, most disease‐associated… read more here.
Keywords: function; gain function; gating domain; itpr1 gating ... See more keywords