Using marker gene analysis instead of mixed lymphocyte reaction assay for identification of functional CD4+FOXP3+ regulatory T cells
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Letters"
DOI: 10.1007/s10529-017-2498-8
Abstract: ObjectiveTo establish a quick analytical method using quantitative PCR for marker gene analysis to identify the functions of iTreg cells and subsequently curtail the harvest time for iTreg cells.ResultsThe data from the marker gene analysis… read more here.
Keywords: gene; marker gene; itreg cells; gene analysis ... See more keywords
Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.01.070
Abstract: Summary Regulatory T (Treg) cells are critical in regulating the immune response. In vitro induced Treg (iTreg) cells have significant potential in clinical medicine. However, applying iTreg cells as therapeutics is complicated by the poor… read more here.
Keywords: human itreg; hic1; function; itreg ... See more keywords
PD‐1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.05.006
Abstract: SUMMARY CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death‐1 receptor (PD‐1) signaling imparted regulatory phenotype… read more here.
Keywords: th1 cells; aep; asparaginyl endopeptidase; itreg cells ... See more keywords
Enhanced CD25+Foxp3+ regulatory T cell development by amodiaquine through activation of nuclear receptor 4A
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17073-y
Abstract: CD4+ T cells play key roles in the regulation of immune responses against pathogenic infectious antigens via development into effector T helper and induced regulatory T (iTreg) cells. Particularly, CD4+CD25+Foxp3+ iTreg cells are crucial for… read more here.
Keywords: cell development; itreg cell; development; cell ... See more keywords
Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity
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DOI: 10.1038/s41598-024-68098-z
Abstract: The molecular mechanisms that govern differential T cell development from CD4+CD25-conventional T (Tconv) into CD4+CD25+ forkhead-box-P3+ (FoxP3+) inducible regulatory T (iTreg) cells remain unclear. Herein, we investigated the relative contribution of protein kinase A (PKA)… read more here.
Keywords: foxp3; protein kinase; deciphering role; autoimmunity ... See more keywords
Expression and Function of Nicotinic Acetylcholine Receptors in Induced Regulatory T Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031779
Abstract: A contribution of the cholinergic system to immune cell function has been suggested, though the role of nicotine and its receptors in T cells, especially regulatory T (Treg) cells, is unclear. We herein investigated the… read more here.
Keywords: function nicotinic; itreg cells; nicotinic acetylcholine; expression ... See more keywords