Design and Validation of Inducible TurboCARsTM with Tunable Induction and Combinatorial Cytokine Signaling.
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DOI: 10.1158/2326-6066.cir-21-0253
Abstract: Although cytokine support can enhance CAR T-cell function, co-administering cytokines or engineering CAR T cells to secrete cytokines can result in toxicities. To mitigate these safety risks, we engineered iTurboCARTM T cells that coexpress a… read more here.
Keywords: cytokine; cytokine signaling; iturbo domains; design validation ... See more keywords