Ivabradine in Cardiovascular Disease Management Revisited: a Review
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-020-07124-4
Abstract: Ivabradine is a unique agent that is distinct from beta-blockers and calcium channel blockers as it reduces heart rate without affecting myocardial contractility or vascular tone. Ivabradine is a use-dependent inhibitor targeting the sinoatrial node.… read more here.
Keywords: ivabradine cardiovascular; heart; heart failure; cardiovascular disease ... See more keywords
Ivabradine for the Treatment of Postural Orthostatic Tachycardia Syndrome: A Systematic Review
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-017-0252-1
Abstract: IntroductionPostural orthostatic tachycardia syndrome (POTS) impacts millions of patients, but there is currently no gold standard treatment for this condition. Ivabradine is a novel heart rate (HR) lowering agent that acts on the sinoatrial node… read more here.
Keywords: treatment; systematic review; tachycardia; orthostatic tachycardia ... See more keywords
Effect of ivabradine on major adverse cardiovascular events and mortality in critically ill patients: a systematic review and meta-analyses of randomised controlled trials with trial sequential analyses.
Sign Up to like & getrecommendations! Published in 2020 at "British journal of anaesthesia"
DOI: 10.1016/j.bja.2020.01.027
Abstract: BACKGROUND Ivabradine lowers heart rate (HR) without affecting contractility or vascular tone. It is licensed for HR control in chronic heart diseases. We performed a systematic review and meta-analyses to examine whether ivabradine could decrease… read more here.
Keywords: meta analyses; trial; review meta; systematic review ... See more keywords
Hemodynamic Effect of Ivabradine in Young Girl with Acute Heart Failure
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1972
Abstract: Introduction Few data are currently available on the use of Ivabradine in children with heart failure (HF). This medication has recently proved to be useful in decreasing heart rate (HR) and in improving left ventricular… read more here.
Keywords: girl; heart; case; ivabradine ... See more keywords
Ivabradine modulates the autonomic nervous system by affecting the "little brain" of the heart: A hypothesis.
Sign Up to like & getrecommendations! Published in 2019 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2019.109253
Abstract: Ivabradine decreases heart rate by selective inhibition of the If current in the sinoatrial node. Ivabradine is declared to have no direct effect on the autonomic nervous system (ANS). However, there are some data suggesting… read more here.
Keywords: heart; nervous system; autonomic nervous; ivabradine ... See more keywords
COST-EFFECTIVENESS ANALYSIS OF IVABRADINE IN TREATMENT OF PATIENTS WITH HEART FAILURE IN IRAN
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Technology Assessment in Health Care"
DOI: 10.1017/s0266462318003598
Abstract: Objectives: This study aimed to assess the cost-effectiveness of ivabradine plus standard of care (SoC) in comparison with current SoC alone from the Iranian payer perspective. Methods: A cohort-based Markov model was developed to assess… read more here.
Keywords: heart; analysis; cost; cost effectiveness ... See more keywords
Ivabradine for treatment of heart failure
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Safety"
DOI: 10.1080/14740338.2019.1612873
Abstract: ABSTRACT Introduction: Heart failure with reduced ejection fraction (HFrEF) is associated with a worse outcome. Heart rate (HR) is related to outcome in HFrEF. Ivabradine selectively inhibits If (funny) channels in a concentration-dependent manner reducing… read more here.
Keywords: heart; treatment; heart failure; hfref ... See more keywords
Heart Rate Control during Experimental Sepsis in Mice: Comparison of Ivabradine and β-Blockers.
Sign Up to like & getrecommendations! Published in 2019 at "Anesthesiology"
DOI: 10.1097/aln.0000000000003045
Abstract: WHAT WE ALREADY KNOW ABOUT THIS TOPIC Tachycardia is known to occur with sepsis and can result in decreased ventricular filling and increased myocardial oxygen demand.β-Blockers or ivabradine (a selective inhibitor of If channels in… read more here.
Keywords: ivabradine; sepsis; mice; heart rate ... See more keywords
Possible Ameliorative Effect of Ivabradine on the Autonomic and Left Ventricular Dysfunction Induced by Doxorubicin in Male Rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000586
Abstract: Abstract: Heart failure is a common adverse effect associated with doxorubicin treatment. The aim of this study is to investigate the effect of ivabradine treatment on doxorubicin-induced heart failure in conscious rats. Rats were treated… read more here.
Keywords: heart; effect ivabradine; heart failure; left ventricular ... See more keywords
Ivabradine's Pleiotropic Profile: Can It Protect Against Doxorubicin-Induced Heart Failure?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000597
Abstract: More than 2 decades ago, a novel sinoatrial (SA) node modulator, now known as ivabradine, was found in experimental preparations to decrease heart rate to a similar extent as beta-blockers but without depressing cardiac index… read more here.
Keywords: heart; heart failure; rate; doxorubicin ... See more keywords
A randomised, double blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial.
Sign Up to like & getrecommendations! Published in 2019 at "Pain"
DOI: 10.1097/j.pain.0000000000001638
Abstract: Preclinical studies suggest that type 2 hyperpolarization-activated cyclic nucleotide gated ion channels (HCN2) are necessary for neuropathic pain. This trial assessed the influence of ivabradine, a non-selective HCN channel blocker, on capsaicin-induced hyperalgesia and pain… read more here.
Keywords: trial; hcn channel; channel blocker; placebo ... See more keywords