Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206296
Abstract: The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae. Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs, a single‐cell transcriptomic atlas mapping early IVD formation is still… read more here.
Keywords: cell; ivd; single cell; intervertebral disc ... See more keywords
Optimisation of Intervertebral Disc Mechanical Properties and the Impact of Vertebral Alignment in Subject‐Specific Finite Element Models
Sign Up to like & getrecommendations! Published in 2025 at "International Journal for Numerical Methods in Biomedical Engineering"
DOI: 10.1002/cnm.70052
Abstract: Subject‐specific finite element models could improve understanding of how spinal loading varies between people, based on differences in morphology and tissue properties. However, determining accurate subject‐specific intervertebral disc (IVD) properties can be difficult due to… read more here.
Keywords: subject specific; finite element; model; ivd ... See more keywords
The importance of level stratification for quantitative MR studies of lumbar intervertebral discs: a cross-sectional analysis in 101 healthy adults
Sign Up to like & getrecommendations! Published in 2019 at "European Spine Journal"
DOI: 10.1007/s00586-019-06059-1
Abstract: To investigate whether quantitative T2-times depend on lumbar intervertebral disc (IVD) level. The lumbar spine (Th12/L1–L5/S1) of 101 participants (53.5% female, 30.0[± 3.6]years, 173.5[± 9.6]cm and 69.9[± 13.4]kg), without history of back pain, was examined on a 3T… read more here.
Keywords: pfirrmann grade; lumbar intervertebral; time; level ... See more keywords
A double instrumental variable method for geophysical product error estimation
Sign Up to like & getrecommendations! Published in 2019 at "Remote Sensing of Environment"
DOI: 10.1016/j.rse.2019.03.003
Abstract: The global validation of remotely sensed and/or modeled geophysical products is often complicated by a lack of suitable ground observations for comparison. By cross-comparing three independent collocated observations, triple collocation (TC) can solve for geophysical… read more here.
Keywords: instrumental variable; ivd; method; product error ... See more keywords
Zur Umsetzung der Verordnung (EU) 2017/746 vom 5. April 2017 über In-vitro-Diagnostika (IVDR) in medizinischen Laboratorien, insbesondere in der Ophthalmopathologie
Sign Up to like & getrecommendations! Published in 2022 at "Klinische Monatsblatter fur Augenheilkunde"
DOI: 10.1055/a-1863-9331
Abstract: Die Europäische Kommission hat die Richtlinie 98/79/EG über In-vitro-Diagnostika (IVDD) überarbeitet, um die Sicherheit der Patienten zu verbessern und dem technischen Fortschritt angemessen Rechnung zu tragen. Mit der neuen Verordnung (EU) 2017/746 vom 25. Mai… read more here.
Keywords: ivdr; 2017 746; ivd; der ... See more keywords
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2017 at "SPINE"
DOI: 10.1097/brs.0000000000001982
Abstract: Study Design. Laboratory study. Objective. To elucidate the potential involvement of the interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducers and activator of transcription (STAT3) pathway in the development of intervertebral disc (IVD) degeneration. Summary of Background Data.… read more here.
Keywords: stat3 pathway; potential involvement; ivd; jak stat3 ... See more keywords
Immunomodulation of Human Mesenchymal Stem/Stromal Cells in Intervertebral Disc Degeneration: Insights From a Proinflammatory/Degenerative Ex Vivo Model
Sign Up to like & getrecommendations! Published in 2018 at "SPINE"
DOI: 10.1097/brs.0000000000002494
Abstract: Study Design. Ex vivo experimental study. Objective. To investigate the effect of proinflammatory/degenerative intervertebral disc (IVD) microenvironment on the regenerative and immunomodulatory behavior of mesenchymal stem/stromal cells (MSCs), using an ex vivo model from bovine… read more here.
Keywords: stem stromal; proinflammatory degenerative; ivd; intervertebral disc ... See more keywords
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12800
Abstract: Intervertebral disk (IVD) degeneration is a prevalent age‐associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis… read more here.
Keywords: homeostasis; intervertebral disk; foxo; homeostasis aging ... See more keywords
Tissue physiology revolving around the clock: circadian rhythms as exemplified by the intervertebral disc
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-219515
Abstract: Circadian clocks in the brain and peripheral tissues temporally coordinate local physiology to align with the 24 hours rhythmic environment through light/darkness, rest/activity and feeding/fasting cycles. Circadian disruptions (during ageing, shift work and jet-lag) have been… read more here.
Keywords: circadian rhythms; ivd; physiology; circadian clocks ... See more keywords
Mitochondrial Dysfunction in Intervertebral Disc Degeneration: From Pathogenesis to Therapeutic Target
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/8880320
Abstract: Mitochondria are cytosolic organelles essential for cellular function and survival. The function of mitochondria is maintained by mitochondrial quality control systems including mitochondrial fission and fusion to adapt the altered environment and mitophagy for removal… read more here.
Keywords: dysfunction; ivd; intervertebral disc; mitochondrial dysfunction ... See more keywords
Assessing operational readiness: Regulatory landscape and compliance in zimbabwe for medical devices and in vitro diagnostic medical devices
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0287495
Abstract: The regulation of medical devices and In Vitro Diagnostic (IVD) medical devices have lagged significantly, especially in low- and middle-income countries. Disparities in regulating medical and IVD medical devices in Africa are below the global… read more here.
Keywords: market; operational readiness; devices vitro; ivd ... See more keywords