Injectable biomaterial induces regeneration of the intervertebral disc in a caprine loaded disc culture model.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d3bm00150d
Abstract: Back pain is the leading cause of disability with half of cases attributed to intervertebral disc (IVD) degeneration, yet currently no therapies target this cause. We previously reported an ex vivo caprine loaded disc culture… read more here.
Keywords: culture; degeneration; caprine loaded; ivd degeneration ... See more keywords
10-year Longitudinal MRI Study of Intervertebral Disk Degeneration in Patients With Lumbar Spinal Canal Stenosis After Posterior Lumbar Decompression Surgery
Sign Up to like & getrecommendations! Published in 2023 at "Spine"
DOI: 10.1097/brs.0000000000004671
Abstract: Study Design. A prospective longitudinal magnetic resonance imaging (MRI) study. Objective. The objective of this study was to describe the progression of intervertebral disk (IVD) degeneration in patients who underwent posterior decompression surgery for lumbar… read more here.
Keywords: ivd degeneration; progression; degeneration; decompression surgery ... See more keywords
RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-1886-3
Abstract: BackgroundLow back pain has become a serious social and economic burden and the leading cause of disability worldwide. Among a variety of pathophysiological triggers, intervertebral disc (IVD) degeneration plays a primary underlying role in causing… read more here.
Keywords: ripk1; caspase; ivd degeneration; pathology ... See more keywords
Pulsed Electromagnetic Field Alleviates Intervertebral Disc Degeneration by Activating Sirt1-Autophagy Signaling Network
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.853872
Abstract: Intervertebral disc (IVD) degeneration is regarded as a major contributor to low back pain (LBP), causing serious economic burden on individuals and society. Unfortunately, there are limited effective treatment for IVD degeneration. Pulsed electromagnetic field… read more here.
Keywords: degeneration; pemf; ivd degeneration; intervertebral disc ... See more keywords
Fexofenadine Protects Against Intervertebral Disc Degeneration Through TNF Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.687024
Abstract: Objective: Fexofenadine (FFD) is an antihistamine drug with an anti-inflammatory effect. The intervertebral disc (IVD) degeneration process is involved in inflammation in which tumor necrosis factor-α (TNF-α) plays an important role. This study aims to… read more here.
Keywords: tnf; ivd degeneration; degeneration; intervertebral disc ... See more keywords
Macrophages Down-Regulate Gene Expression of Intervertebral Disc Degenerative Markers Under a Pro-inflammatory Microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01508
Abstract: Low back pain is a highly prevalent clinical problem and intervertebral disc (IVD) degeneration is now accepted as the major pathophysiological mechanism responsible for this condition. Accumulating evidence suggests that inflammation plays a crucial role… read more here.
Keywords: ivd degeneration; gene expression; ivd; expression ... See more keywords
Degenerative Nucleus Pulposus Cells Derived Exosomes Promoted Cartilage Endplate Cells Apoptosis and Aggravated Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.835976
Abstract: Intervertebral disc (IVD) degeneration is a complex multifactorial disease model, which pathogenesis has not been fully defined. There are few studies on the information interaction between nucleus pulposus (NP) cells and cartilage endplate (CEP) cells.… read more here.
Keywords: degeneration; ivd degeneration; intervertebral disc; cartilage endplate ... See more keywords
Selection of the Optimal Puncture Needle for Induction of a Rat Intervertebral Disc Degeneration Model.
Sign Up to like & getrecommendations! Published in 2019 at "Pain physician"
DOI: 10.36076/ppj/2019.22.353
Abstract: BACKGROUND The incidence of intervertebral disc (IVD) degeneration has increased in recent years. A simple, reliable, and reproducible animal model is critical for understanding the underlying mechanisms of IVD degeneration. The caudal discs of rats… read more here.
Keywords: ivd degeneration; gauge needle; model; intervertebral disc ... See more keywords