Progress in the Application of Hydrogels in Intervertebral Disc Repair: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2024 at "Current Pain and Headache Reports"
DOI: 10.1007/s11916-024-01296-6
Abstract: Intervertebral disc degeneration (IVDD) is a common orthopaedic disease and an important cause of lower back pain, which seriously affects the work and life of patients and causes a large economic burden to society. The… read more here.
Keywords: ivdd; application hydrogels; intervertebral disc; hydrogels intervertebral ... See more keywords
Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2035773
Abstract: Abstract Context Cyanidin has been shown to have therapeutic potential in osteoarthritis. However, it is unclear whether cyanidin prevents the progression of intervertebral disc degeneration (IVDD). Objective This study evaluates the effects of cyanidin on… read more here.
Keywords: vitro vivo; ivdd; cyanidin; jak2 ... See more keywords
Omentin-1 alleviate interleukin-1β(IL-1β)-induced nucleus pulposus cells senescence
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2084495
Abstract: ABSTRACT One of the main causes of low back pain (LBP) and degenerative musculoskeletal disorders is intervertebral disc degeneration (IVDD). Inflammation-associated senescence of Human nucleus pulposus cells (HNPCs) plays an essential function in the disease… read more here.
Keywords: omentin; ivdd; senescence; nucleus pulposus ... See more keywords
Uncovering potential drug targets for lactylation-related genes mediated intervertebral disc degeneration: A Mendelian randomization analysis integrating eQTL data
Sign Up to like & getrecommendations! Published in 2025 at "Medicine"
DOI: 10.1097/md.0000000000044382
Abstract: Intervertebral disc degeneration (IVDD) is a common cause of neck, back, and low back pain, it is also a major global public health problem. Lactate is a metabolic product of intervertebral disc cells and is… read more here.
Keywords: ivdd; disc degeneration; intervertebral disc; related genes ... See more keywords
Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/2776440
Abstract: The abnormal function of nucleus pulposus cells (NPCs) plays a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). Recent studies have demonstrated that circular RNAs (circRNAs) are involved in the pathological process of… read more here.
Keywords: disc degeneration; intervertebral disc; inflammatory; circ 0040039 ... See more keywords
Development and Validation of a Novel Nomogram to Predict the Risk of Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Mediators of Inflammation"
DOI: 10.1155/2022/3665934
Abstract: Intervertebral disc degeneration (IVDD) has been a complex disorder resulted from genetic and environmental risk factors. The aim of this study was to identify the risk factors associated with IVDD in orthopaedic patients and develop… read more here.
Keywords: ivdd; validation; group; risk ... See more keywords
Piezo1 promotes intervertebral disc degeneration through the Ca2+/F-actin/Yap signaling axis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Medicine"
DOI: 10.1186/s10020-025-01147-z
Abstract: Piezo1 is a mechanically sensitive cation channel expressed in various tissues of the human body and has multiple roles in both physiological and pathological processes. However, its role in the occurrence and development of intervertebral… read more here.
Keywords: ivdd; intervertebral disc; yap; degeneration ... See more keywords
Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2020 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-020-03329-8
Abstract: Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Although the mechanism of degeneration remains unclear, aging has been recognized as a key risk factor for IVDD. Most studies seeking to… read more here.
Keywords: differential proteomic; proteomic analysis; ivdd; age related ... See more keywords
CLEC11A-Driven Molecular Mechanisms in Intervertebral Disc Degeneration: A Comprehensive Multi-Omics Study
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s505296
Abstract: Background Intervertebral disc degeneration (IVDD) is a common chronic degenerative disease with a complex etiology involving genetic and environmental factors. However, the genetic pathogenesis and key driving factors of IVDD remain largely unknown. Methods In… read more here.
Keywords: ivdd; disc degeneration; intervertebral disc; multi omics ... See more keywords
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.823945
Abstract: Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP)… read more here.
Keywords: disc degeneration; intervertebral disc; ivdd; senolytics eliminating ... See more keywords
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.611234
Abstract: Intervertebral disc degeneration (IVDD) has been reported to be a major cause of low back pain. Studies have demonstrated that IVDD may be dysregulated at the transcriptional level; however, whether post-transcriptional regulation is involved is… read more here.
Keywords: hur; inflammation; rna binding; intervertebral disc ... See more keywords