Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2035773
Abstract: Abstract Context Cyanidin has been shown to have therapeutic potential in osteoarthritis. However, it is unclear whether cyanidin prevents the progression of intervertebral disc degeneration (IVDD). Objective This study evaluates the effects of cyanidin on… read more here.
Keywords: vitro vivo; ivdd; cyanidin; jak2 ... See more keywords
Omentin-1 alleviate interleukin-1β(IL-1β)-induced nucleus pulposus cells senescence
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DOI: 10.1080/21655979.2022.2084495
Abstract: ABSTRACT One of the main causes of low back pain (LBP) and degenerative musculoskeletal disorders is intervertebral disc degeneration (IVDD). Inflammation-associated senescence of Human nucleus pulposus cells (HNPCs) plays an essential function in the disease… read more here.
Keywords: omentin; ivdd; senescence; nucleus pulposus ... See more keywords
Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration
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DOI: 10.1155/2022/2776440
Abstract: The abnormal function of nucleus pulposus cells (NPCs) plays a crucial role in the pathogenesis of intervertebral disc degeneration (IVDD). Recent studies have demonstrated that circular RNAs (circRNAs) are involved in the pathological process of… read more here.
Keywords: disc degeneration; intervertebral disc; inflammatory; circ 0040039 ... See more keywords
Development and Validation of a Novel Nomogram to Predict the Risk of Intervertebral Disc Degeneration
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DOI: 10.1155/2022/3665934
Abstract: Intervertebral disc degeneration (IVDD) has been a complex disorder resulted from genetic and environmental risk factors. The aim of this study was to identify the risk factors associated with IVDD in orthopaedic patients and develop… read more here.
Keywords: ivdd; validation; group; risk ... See more keywords
Differential proteomic analysis of fetal and geriatric lumbar nucleus pulposus: immunoinflammation and age-related intervertebral disc degeneration
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DOI: 10.1186/s12891-020-03329-8
Abstract: Background Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Although the mechanism of degeneration remains unclear, aging has been recognized as a key risk factor for IVDD. Most studies seeking to… read more here.
Keywords: differential proteomic; proteomic analysis; ivdd; age related ... See more keywords
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
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DOI: 10.3389/fbioe.2022.823945
Abstract: Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP)… read more here.
Keywords: disc degeneration; intervertebral disc; ivdd; senolytics eliminating ... See more keywords
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.611234
Abstract: Intervertebral disc degeneration (IVDD) has been reported to be a major cause of low back pain. Studies have demonstrated that IVDD may be dysregulated at the transcriptional level; however, whether post-transcriptional regulation is involved is… read more here.
Keywords: hur; inflammation; rna binding; intervertebral disc ... See more keywords
IGF Signaling in Intervertebral Disc Health and Disease
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DOI: 10.3389/fcell.2021.817099
Abstract: Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD). However, pathogenesis… read more here.
Keywords: signaling intervertebral; igf signaling; ivdd; intervertebral disc ... See more keywords
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.819262
Abstract: Intervertebral disc degeneration (IVDD) is the primary cause of low back pain; however, the molecular mechanisms involved in the pathogenesis of IVDD are not fully understood. Polo-like kinase 1 (PLK1) plays numerous roles in the… read more here.
Keywords: disc degeneration; senescence; nucleus pulposus; ivdd ... See more keywords
Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling
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DOI: 10.3389/fendo.2022.994307
Abstract: Background context Low back pain, affecting nearly 40% of adults, mainly results from intervertebral disc degeneration (IVDD), while the pathogenesis of IVDD is still not fully elucidated. Recently, some researches have revealed that necroptosis, a… read more here.
Keywords: necroptosis; signaling necroptosis; ivdd; necroptosis cells ... See more keywords
Morroniside attenuates nucleus pulposus cell senescence to alleviate intervertebral disc degeneration via inhibiting ROS-Hippo-p53 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.942435
Abstract: Intervertebral disc (IVD) degeneration (IVDD) which is highly prevalent within the elderly population, is a leading cause of chronic low back pain and disability. Nucleus pulposus (NP) cell senescence plays an indispensable role in the… read more here.
Keywords: ivdd; morroniside; senescence; p53 ... See more keywords