Impact of childhood maltreatment on aging: a comprehensive Mendelian randomization analysis of multiple age-related biomarkers
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Epigenetics"
DOI: 10.1186/s13148-024-01720-z
Abstract: Childhood maltreatment (CM) is linked to long-term adverse health outcomes, including accelerated biological aging and cognitive decline. This study investigates the relationship between CM and various aging biomarkers: telomere length, facial aging, intrinsic epigenetic age… read more here.
Keywords: age; ivw pfdr; mendelian randomization; telomere length ... See more keywords
Global Spatiotemporal Trends and Modifiable Risk Factors for Female Infertility: An Age-Period-Cohort Using Global Burden of Disease Study 2021 and Mendelian Randomization Analysis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Women's Health"
DOI: 10.2147/ijwh.s543096
Abstract: Background This study aims to describe the global burden of female infertility, analyze its spatial and temporal trends, and offer targeted epidemiological insights to support the prevention and management of female infertility. Methods Drawing on… read more here.
Keywords: age; infertility; female infertility; ivw pfdr ... See more keywords
Causal relationships between gut microbiota and programmed cell death protein 1/programmed cell death-ligand 1: A bidirectional Mendelian randomization study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1136169
Abstract: Background Multiple clinical studies have indicated that the gut microbiota influences the effects of immune checkpoint blockade (ICB) therapy comprising PD-1/PD-L1 inhibitors, but the causal relationship is unclear. Because of numerous confounders, many microbes related… read more here.
Keywords: ivw pfdr; cell death; microbiota; programmed cell ... See more keywords