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   Articles with "jag1" as a keyword



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A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells.

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recommendations! Published in 2019 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2018.12.002

Abstract: During craniofacial development, cranial neural crest (CNC) cells migrate into the developing face and form bone through intramembranous ossification. Loss of JAGGED1 (JAG1) signaling in the CNC cells is associated with maxillary hypoplasia or maxillary… read more here.

Keywords: cnc cells; jag1; non canonical; jagged1 ... See more keywords

In silico analysis, seasonal variation and gonadotropic regulation of jag1 and its receptor notch1 in testis of spotted snakehead Channa punctatus.

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recommendations! Published in 2018 at "General and comparative endocrinology"

DOI: 10.1016/j.ygcen.2018.05.014

Abstract: The present study in seasonally breeding spotted snakehead Channa punctatus, for the first time in nonmammalian vertebrates, demonstrated correlation between reproductive phase-dependent testicular expression of ligand Jag1/receptor Notch1 and spermatogenic events. Testicular transcriptome sequencing data… read more here.

Keywords: punctatus; cpjag1; jag1; expression ... See more keywords
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Jagged-1 induced molecular alterations in HPV associated invasive squamous cell and adenocarcinoma of the human uterine cervix

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-27699-1

Abstract: The majority of cervical cancer (CC) cases are attributable to HPV infection. Altered Notch pathway signals and HPV are believed to modify clinicopathogenesis of CC, however, the involvement of each molecular player and its mechanism… read more here.

Keywords: jag1; induced molecular; molecular alterations; hpv associated ... See more keywords
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Hematopoietic Jagged1 is a fetal liver niche factor required for functional maturation and engraftment of fetal hematopoietic stem cells.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2210058120

Abstract: Notch signaling is essential for the emergence of definitive hematopoietic stem cells (HSCs) in the embryo and their development in the fetal liver niche. However, how Notch signaling is activated and which fetal liver cell… read more here.

Keywords: fetal liver; notch signaling; liver; jag1 ... See more keywords
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LINC00173 regulates polycystic ovarian syndrome progression by promoting apoptosis and repressing proliferation in ovarian granulosa cells via the microRNA-124-3p (miR-124-3p)/jagged canonical Notch ligand 1 (JAG1) pathway.

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2053797

Abstract: As an endocrine and metabolic disorder, polycystic ovarian syndrome (PCOS) is common in females at childbearing age. Our work was intended to uncover the underlying role of LINC00173 and its potential regulatory mechanism in PCOS… read more here.

Keywords: linc00173; jag1; kgn cells; apoptosis ... See more keywords
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Antisense oligonucleotide silencing of a glycosyltransferase, Poglut1, improves the liver phenotypes in mouse models of Alagille syndrome.

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recommendations! Published in 2023 at "Hepatology"

DOI: 10.1097/hep.0000000000000380

Abstract: BACKGROUND AND AIMS Paucity of intrahepatic bile ducts is caused by various etiologies and often leads to cholestatic liver disease. For example, in patients with Alagille syndrome (ALGS), which is a genetic disease primarily caused… read more here.

Keywords: antisense oligonucleotide; jag1; alagille syndrome; liver phenotypes ... See more keywords
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Functional characterization of a JAG1 5'UTR variant in a patient with clinically observed Alagille syndrome

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recommendations! Published in 2022 at "Clinical Genetics"

DOI: 10.1111/cge.14179

Abstract: Alagille syndrome (ALGS) is an autosomal dominant disorder characterized by variable abnormalities of liver, heart, face, skeleton, kidneys, vasculature and eyes. It is associated with variants in JAG1 and NOTCH2 , encoding for a NOTCH… read more here.

Keywords: functional characterization; jag1; characterization jag1; alagille syndrome ... See more keywords
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An N-glycan on the C2 domain of JAGGED1 is important for Notch activation

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recommendations! Published in 2022 at "Science Signaling"

DOI: 10.1126/scisignal.abo3507

Abstract: The canonical members of the Jagged/Serrate and Delta families of transmembrane ligands have an extracellular, amino-terminal C2 domain that binds to phospholipids and is required for optimal activation of the Notch receptor. Somatic mutations that… read more here.

Keywords: jag1; domain; glycosylation; notch ... See more keywords
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LncRNA KCNQ1OT1 promotes cell proliferation, migration and invasion via regulating miR-129-5p/JAG1 axis in non-small cell lung cancer

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recommendations! Published in 2020 at "Cancer Cell International"

DOI: 10.1186/s12935-020-01225-8

Abstract: Background Non-small cell lung cancer (NSCLC) is the most deadly cancer worldwide. LncRNA KCNQ1OT1 has been reported to be involved in the progression of various tumors, including NSCLC. However, the precise mechanism of KCNQ1OT1 in… read more here.

Keywords: jag1; mir 129; kcnq1ot1; cell ... See more keywords
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IncRNA MIAT Accelerates Keloid Formation by miR-411-5p/JAG1 Axis.

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recommendations! Published in 2023 at "Critical reviews in eukaryotic gene expression"

DOI: 10.1615/critreveukaryotgeneexpr.2022044734

Abstract: The long non-coding RNA (lncRNA) myocardial infarction-associated transcript (MIAT) regulates the biological functions of many kinds of cells. The aim of this study is to explore the mechanism of MIAT and how it affects keloid… read more here.

Keywords: miat accelerates; mir 411; miat jag1; jag1 ... See more keywords
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Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.16969

Abstract: Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal and adult regenerative angiogenesis. In tumours, both ligands are upregulated… read more here.

Keywords: angiogenesis; jag1; tumour growth; tumour angiogenesis ... See more keywords