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   Articles with "jagged1" as a keyword



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TGFβ signaling controls intrahepatic bile duct development may through regulating the Jagged1‐Notch‐Sox9 signaling axis

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recommendations! Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26304

Abstract: Due to the inherent limitations of the mouse models, the molecular mechanism of TGFβ signaling involved in the development of intrahepatic bile ducts (IHBDs) has been investigated little. Here, we investigated the role of TGFβ… read more here.

Keywords: tgf signaling; notch; tgf; sox9 ... See more keywords
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Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients

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recommendations! Published in 2017 at "Breast Cancer Research and Treatment"

DOI: 10.1007/s10549-017-4394-2

Abstract: PurposeEndocrine resistance limits the efficacy of anti-estrogen therapies. Notch signaling is involved in modulating tumor-associated macrophage (TAM) differentiation and is upregulated in endocrine-resistant breast cancer cells. Here, we analyzed the role of Jagged1 in the… read more here.

Keywords: breast cancer; resistance; macrophage; jagged1 ... See more keywords
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Breaking Down Barriers to Chemoresistance: Role of Chemotherapy-Induced Osteoblastic Jagged1.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.11.016

Abstract: Bone metastases are incurable. The bone microenvironment has always been a suspect for this clinical enigma, but the exact mechanisms have been unclear. In this issue of Cancer Cell, Zheng and colleagues provide evidence that… read more here.

Keywords: chemotherapy; breaking barriers; chemoresistance role; role chemotherapy ... See more keywords
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A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells.

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recommendations! Published in 2019 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2018.12.002

Abstract: During craniofacial development, cranial neural crest (CNC) cells migrate into the developing face and form bone through intramembranous ossification. Loss of JAGGED1 (JAG1) signaling in the CNC cells is associated with maxillary hypoplasia or maxillary… read more here.

Keywords: cnc cells; jag1; non canonical; jagged1 ... See more keywords
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Indirect immobilized Jagged1 suppresses cell cycle progression and induces odonto/osteogenic differentiation in human dental pulp cells

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-10638-x

Abstract: Notch signaling regulates diverse biological processes in dental pulp tissue. The present study investigated the response of human dental pulp cells (hDPs) to the indirect immobilized Notch ligand Jagged1 in vitro. The indirect immobilized Jagged1… read more here.

Keywords: immobilized jagged1; cell cycle; indirect immobilized; dental pulp ... See more keywords
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Knockdown of DANCR reduces osteoclastogenesis and root resorption induced by compression force via Jagged1

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recommendations! Published in 2019 at "Cell Cycle"

DOI: 10.1080/15384101.2019.1632638

Abstract: ABSTRACT LncRNA DANCR has been proven to be involved in osteoblast differentiation. This study aims to investigate the role of DANCR in osteoclast formation and root resorption in periodontal ligament (PDL) cells induced by compression… read more here.

Keywords: knockdown dancr; induced compression; resorption; jagged1 ... See more keywords

miR‐21 promotes cardiac fibroblast‐to‐myofibroblast transformation and myocardial fibrosis by targeting Jagged1

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recommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.13654

Abstract: Myocardial fibrosis after myocardial infarction (MI) is a leading cause of heart diseases. MI activates cardiac fibroblasts (CFs) and promotes CF to myofibroblast transformation (CMT). This study aimed to investigate the role of miR‐21 in… read more here.

Keywords: mir; jagged1; myocardial fibrosis; myofibroblast transformation ... See more keywords
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SOX12 Promotes Stem Cell-Like Phenotypes and Osteosarcoma Tumor Growth by Upregulating JAGGED1

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recommendations! Published in 2021 at "Stem Cells International"

DOI: 10.1155/2021/9941733

Abstract: SOX12 plays a role in promoting the growth of some tumors; however, its role in osteosarcoma remains unclear. From gene expression omnibus (GEO) and tumor alterations relevant for genomics-driven therapy (TARGET) databases, Kaplan–Meier analyses were… read more here.

Keywords: osteosarcoma; expression; growth; jagged1 ... See more keywords
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Punicalagin Alleviates Aged Bronchial Asthma by Inhibiting Th2 Differentiation through IL-4/STAT6 and Jagged1/Notch Pathways

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recommendations! Published in 2022 at "Journal of Healthcare Engineering"

DOI: 10.1155/2022/1184677

Abstract: Objective To explore the therapeutic effect and mechanism of punicalagin on bronchial asthma in the elderly. Methods Peripheral venous blood was collected from healthy people and elderly patients with bronchial asthma. Peripheral blood mononuclear cells… read more here.

Keywords: stat6 jagged1; jagged1; healthy people; bronchial asthma ... See more keywords
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Notch1 activation of Jagged1 contributes to differentiation of mesenchymal stem cells into endothelial cells under cigarette smoke extract exposure

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recommendations! Published in 2022 at "BMC Pulmonary Medicine"

DOI: 10.1186/s12890-022-01913-3

Abstract: Background Mesenchymal stem cells (MSCs) have shown therapeutic potential for engraftment to, differentiation into, endothelial cells (ECs). However, low-efficiency yields hinder their use as ECs for therapeutic vascularization. Methods The Notch1 signaling pathway is key… read more here.

Keywords: differentiation; mesenchymal stem; stem cells; cigarette smoke ... See more keywords
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Interleukin-1beta (IL-1β)-induced Notch ligand Jagged1 suppresses mitogenic action of IL-1β on human dystrophic myogenic cells

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0188821

Abstract: Duchenne muscular dystrophy (DMD) is a severe X-linked recessive muscle disorder caused by mutations in the dystrophin gene. Nonetheless, secondary processes involving perturbation of muscle regeneration probably exacerbate disease progression, resulting in the fatal loss… read more here.

Keywords: myogenic cells; dystrophic myogenic; non dystrophic; dmd myogenic ... See more keywords