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   Articles with "jak inhibitors" as a keyword



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Risk of venous thromboembolism associated with Janus kinase inhibitors for rheumatoid arthritis: case presentation and literature review

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recommendations! Published in 2021 at "Clinical Rheumatology"

DOI: 10.1007/s10067-021-05911-4

Abstract: Janus kinase (JAK) inhibitors have been developed as disease-modifying antirheumatic drugs. Despite the positive therapeutic impacts of JAK inhibitors, concerns have been raised regarding the risk of venous thromboembolism (VTE), such as deep vein thrombosis… read more here.

Keywords: risk venous; vte; risk; risk factors ... See more keywords
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The Next Generation of JAK Inhibitors: an Update on Fedratinib, Momelotonib, and Pacritinib

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recommendations! Published in 2020 at "Current Hematologic Malignancy Reports"

DOI: 10.1007/s11899-020-00596-z

Abstract: Ruxolitinib is the first FDA-approved JAK inhibitor for the treatment of myeloproliferative neoplasms and is an effective means of controlling symptom burden and improving splenomegaly. However, a majority of patients will develop disease progression with… read more here.

Keywords: pacritinib; jak; generation jak; myeloproliferative neoplasms ... See more keywords
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Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors

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recommendations! Published in 2021 at "Dermatology and Therapy"

DOI: 10.1007/s13555-021-00596-8

Abstract: Deucravacitinib, a novel, oral, selective inhibitor of tyrosine kinase 2 (TYK2) signaling, acts via an allosteric mechanism by binding to the enzyme’s regulatory domain instead of the catalytic domain. This unique binding provides high functional… read more here.

Keywords: jak; kinase; inhibition; tyk2 ... See more keywords
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JAK inhibitors for the treatment of autoimmune and inflammatory diseases.

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recommendations! Published in 2019 at "Autoimmunity reviews"

DOI: 10.1016/j.autrev.2019.102390

Abstract: Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide… read more here.

Keywords: treatment autoimmune; inflammatory diseases; autoimmune inflammatory; inhibitors treatment ... See more keywords
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JAK inhibitors in dermatology: The promise of a new drug class

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recommendations! Published in 2017 at "Journal of the American Academy of Dermatology"

DOI: 10.1016/j.jaad.2016.12.005

Abstract: &NA; New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–signal transducer and activator of transcription (JAK‐STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are driven… read more here.

Keywords: dermatology; class; inhibitors dermatology; dermatology promise ... See more keywords
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Janus kinase inhibitors in dermatology: Part II. A comprehensive review

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recommendations! Published in 2021 at "Journal of the American Academy of Dermatology"

DOI: 10.1016/j.jaad.2021.06.873

Abstract: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is implicated in the pathogenesis of a number of inflammatory dermatoses. Clinical trials and other studies have demonstrated the efficacy of JAK inhibitors… read more here.

Keywords: kinase inhibitors; dermatology; inhibitors dermatology; janus kinase ... See more keywords
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The role of JAK inhibitors in hematopoietic cell transplantation

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recommendations! Published in 2022 at "Bone Marrow Transplantation"

DOI: 10.1038/s41409-022-01649-y

Abstract: The Janus Kinase (JAK)/Signal Transducers and Activators of Transcription (STAT) pathway is essential for both the regulation of hematopoiesis and the control of inflammation. Disruption of this pathway can lead to inflammatory and malignant disease… read more here.

Keywords: hematopoietic cell; jak; role jak; transplantation ... See more keywords
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Repigmentation in vitiligo using janus kinase (JAK) inhibitors with phototherapy: systematic review and Meta-analysis

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recommendations! Published in 2020 at "Journal of Dermatological Treatment"

DOI: 10.1080/09546634.2020.1735615

Abstract: Abstract Introduction Vitiligo is an autoimmune disorder characterized by progressive loss of melanocytes, leading to cutaneous depigmentation. Vitiligo has significant psychosocial impacts on patients and is challenging to manage with limited treatment options. Recent studies… read more here.

Keywords: response; jak; review meta; systematic review ... See more keywords
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JAK inhibitors for rheumatoid arthritis

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recommendations! Published in 2023 at "Expert Opinion on Investigational Drugs"

DOI: 10.1080/13543784.2023.2199919

Abstract: ABSTRACT Introduction JAK (Janus kinase) is a type of non-receptor tyrosine kinase that includes JAK1, JAK2, JAK3, and Tyk2. Currently, there are five JAK inhibitors approved for treating rheumatoid arthritis. These inhibitors vary in their… read more here.

Keywords: jak inhibitors; inhibitors rheumatoid; rheumatoid arthritis; jak ... See more keywords
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Advances in pharmacotherapy for ulcerative colitis: a focus on JAK1 inhibitors

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recommendations! Published in 2023 at "Expert Opinion on Pharmacotherapy"

DOI: 10.1080/14656566.2023.2200931

Abstract: ABSTRACT Introduction Janus kinase (JAK) inhibitors are an emerging class of small-molecule drugs, providing targeted therapy for a variety of diseases, and have made their way into the treatment of armamentarium of ulcerative colitis (UC)… read more here.

Keywords: advances pharmacotherapy; jak1 inhibitors; jak inhibitors; ulcerative colitis ... See more keywords
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Cytopenic myelofibrosis: prevalence, relevance, and treatment

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recommendations! Published in 2023 at "Expert Opinion on Pharmacotherapy"

DOI: 10.1080/14656566.2023.2203318

Abstract: ABSTRACT Introduction Cytopenic myelofibrosis is increasingly recognized as a phenotype of myelofibrosis presenting with low blood counts, lower driver mutation allele burden, increased likelihood of arising de novo, i.e. primary myelofibrosis, greater genomic complexity, worse… read more here.

Keywords: jak inhibitors; myelofibrosis prevalence; cytopenic myelofibrosis; myelofibrosis ... See more keywords