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   Articles with "jak inhibitors" as a keyword



Low rates of vaccination among atopic dermatitis, alopecia areata, psoriasis, and psoriatic arthritis patients on biologics

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recommendations! Published in 2024 at "Archives of Dermatological Research"

DOI: 10.1007/s00403-024-03037-6

Abstract: Biologics and Janus kinase (JAK) inhibitors are immunomodulating and immunosuppressing medications utilized to treat atopic dermatitis (AD), psoriasis (PSO), psoriatic arthritis (PsA), and alopecia areata (AA). Special recommendations must be considered when prescribing vaccinations in… read more here.

Keywords: psoriatic arthritis; patients biologics; low rates; jak inhibitors ... See more keywords

Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review

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recommendations! Published in 2025 at "Archives of Dermatological Research"

DOI: 10.1007/s00403-025-04301-z

Abstract: Scarring alopecias, including lichen planopilaris, frontal fibrosing alopecia, folliculitis decalvans, central centrifugal cicatricial alopecia, discoid lupus erythematosus, and dissecting cellulitis cause permanent destruction of hair follicles, resulting in patches of hair loss that can be… read more here.

Keywords: review; label use; use biologics; jak inhibitors ... See more keywords
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Risk of venous thromboembolism associated with Janus kinase inhibitors for rheumatoid arthritis: case presentation and literature review

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recommendations! Published in 2021 at "Clinical Rheumatology"

DOI: 10.1007/s10067-021-05911-4

Abstract: Janus kinase (JAK) inhibitors have been developed as disease-modifying antirheumatic drugs. Despite the positive therapeutic impacts of JAK inhibitors, concerns have been raised regarding the risk of venous thromboembolism (VTE), such as deep vein thrombosis… read more here.

Keywords: risk venous; vte; risk; risk factors ... See more keywords

Sometimes Small Is Beautiful: Discovery of the Janus Kinases (JAK) and Signal Transducer and Activator of Transcription (STAT) Pathways and the Initial Development of JAK Inhibitors for IBD Treatment

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recommendations! Published in 2025 at "Digestive Diseases and Sciences"

DOI: 10.1007/s10620-024-08791-1

Abstract: The Janus kinase/signal transducer and activator of transfection (JAK/STAT) system is comprised of multiple cell surface receptors, receptor tyrosine kinases, and signal transducers that are key components of numerous systems involved in malignancy, inflammation, immune… read more here.

Keywords: development jak; transducer activator; jak; jak inhibitors ... See more keywords

The Next Generation of JAK Inhibitors: an Update on Fedratinib, Momelotonib, and Pacritinib

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recommendations! Published in 2020 at "Current Hematologic Malignancy Reports"

DOI: 10.1007/s11899-020-00596-z

Abstract: Ruxolitinib is the first FDA-approved JAK inhibitor for the treatment of myeloproliferative neoplasms and is an effective means of controlling symptom burden and improving splenomegaly. However, a majority of patients will develop disease progression with… read more here.

Keywords: pacritinib; jak; generation jak; myeloproliferative neoplasms ... See more keywords

Selectivity Profile of the Tyrosine Kinase 2 Inhibitor Deucravacitinib Compared with Janus Kinase 1/2/3 Inhibitors

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recommendations! Published in 2021 at "Dermatology and Therapy"

DOI: 10.1007/s13555-021-00596-8

Abstract: Deucravacitinib, a novel, oral, selective inhibitor of tyrosine kinase 2 (TYK2) signaling, acts via an allosteric mechanism by binding to the enzyme’s regulatory domain instead of the catalytic domain. This unique binding provides high functional… read more here.

Keywords: jak; kinase; inhibition; tyk2 ... See more keywords

Evaluating Current and Emergent JAK Inhibitors for Alopecia Areata: A Narrative Review

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recommendations! Published in 2025 at "Dermatology and Therapy"

DOI: 10.1007/s13555-025-01517-9

Abstract: Alopecia areata (AA) is an autoimmune condition characterized by non-scarring hair loss on the scalp, face, and body, affecting approximately 2% of the global population. Current treatments, including topical corticosteroids, topical immunotherapies, and systemic immunosuppressants,… read more here.

Keywords: janus kinase; dermatology; hair; alopecia areata ... See more keywords
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JAK inhibitors for the treatment of autoimmune and inflammatory diseases.

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recommendations! Published in 2019 at "Autoimmunity reviews"

DOI: 10.1016/j.autrev.2019.102390

Abstract: Cytokines play a central role in the pathophysiology of autoimmune and inflammatory diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized as a major target to inhibit the effect of a wide… read more here.

Keywords: treatment autoimmune; inflammatory diseases; autoimmune inflammatory; inhibitors treatment ... See more keywords
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JAK inhibitors in dermatology: The promise of a new drug class

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recommendations! Published in 2017 at "Journal of the American Academy of Dermatology"

DOI: 10.1016/j.jaad.2016.12.005

Abstract: &NA; New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase–signal transducer and activator of transcription (JAK‐STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are driven… read more here.

Keywords: dermatology; class; inhibitors dermatology; dermatology promise ... See more keywords
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Janus kinase inhibitors in dermatology: Part II. A comprehensive review

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recommendations! Published in 2021 at "Journal of the American Academy of Dermatology"

DOI: 10.1016/j.jaad.2021.06.873

Abstract: The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is implicated in the pathogenesis of a number of inflammatory dermatoses. Clinical trials and other studies have demonstrated the efficacy of JAK inhibitors… read more here.

Keywords: kinase inhibitors; dermatology; inhibitors dermatology; janus kinase ... See more keywords
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The role of JAK inhibitors in hematopoietic cell transplantation

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recommendations! Published in 2022 at "Bone Marrow Transplantation"

DOI: 10.1038/s41409-022-01649-y

Abstract: The Janus Kinase (JAK)/Signal Transducers and Activators of Transcription (STAT) pathway is essential for both the regulation of hematopoiesis and the control of inflammation. Disruption of this pathway can lead to inflammatory and malignant disease… read more here.

Keywords: hematopoietic cell; jak; role jak; transplantation ... See more keywords