JAK-STAT signaling shapes the NF-κB response in CLL towards venetoclax sensitivity or resistance via Bcl-XL.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13364
Abstract: Preventing or overcoming resistance to the Bcl‐2 inhibitor venetoclax is an emerging unmet clinical need in patients with chronic lymphocytic leukaemia (CLL). The upregulation of anti‐apoptotic Bcl‐2 members through signalling pathways within the tumor microenvironment… read more here.
Keywords: sensitivity; resistance; cll; jak stat ... See more keywords
Shared Genetic Risk Factors for MS/Psoriasis suggest involvement of IL17 and JAK-STAT signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Annals of neurology"
DOI: 10.1002/ana.26672
Abstract: OBJECTIVE Psoriasis and multiple sclerosis (MS) are complex immune diseases that are mediated by T-cells and share multiple comorbidities. Previous studies have suggested psoriatic patients are at higher risk of MS; however, causal relationships between… read more here.
Keywords: factors psoriasis; risk factors; risk; jak stat ... See more keywords
BJ‐2266 ameliorates experimental autoimmune encephalomyelitis through down‐regulation of the JAK/STAT signaling pathway
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646860
Abstract: CD4+ T cells differentiate into distinct effector subsets upon antigenic stimulation. Cytokines, and micro‐environmental factors present during T‐cell priming, direct differentiation of naïve CD4+ T cells into pro‐inflammatory Th1 and Th17 cells. From extensive screening… read more here.
Keywords: cd4 cells; jak stat; differentiation; autoimmune encephalomyelitis ... See more keywords
TRIM10 binds to IFN‐α/β receptor 1 to negatively regulate type I IFN signal transduction
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202049073
Abstract: The type I interferon (IFN‐I) system is important for antiviral and anticancer immunity. Prolonged activation of IFN/JAK/STAT signaling is closely associated with autoimmune diseases. TRIM10 dysfunction may be associated closely with certain autoimmune disorders. Here,… read more here.
Keywords: stat signaling; jak stat; signaling pathway; ifn jak ... See more keywords
LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR‐548d‐3p to modulate JAK–STAT pathway in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "IUBMB Life"
DOI: 10.1002/iub.2012
Abstract: Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported… read more here.
Keywords: meg3; stat pathway; mir 548d; jak stat ... See more keywords
Umbelliferone attenuates diabetic cardiomyopathy by suppression of JAK/STAT signaling pathway through amelioration of oxidative stress and inflammation in rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23296
Abstract: Umbelliferone (UMB), 7‐hydroxycoumarin, is a naturally occurring coumarin derivative that has a plethora of biological and therapeutic activities. The focus of this research was to elucidate the curative effects of two different doses of UMB… read more here.
Keywords: stat signaling; signaling pathway; oxidative stress; jak stat ... See more keywords
MicroRNA-495 alleviates ulcerative interstitial cystitis via inactivating the JAK–STAT signaling pathway by inhibiting JAK3
Sign Up to like & getrecommendations! Published in 2021 at "International Urogynecology Journal"
DOI: 10.1007/s00192-020-04593-x
Abstract: As a notable chronic disorder, the incidence of interstitial cystitis (IC) has been documented to have increased among the female population with activity in microRNA-495 (miR-495) implicated in this disease. The current study was aimed… read more here.
Keywords: jak3; mir 495; interstitial cystitis; jak stat ... See more keywords
Comprehensive assessment of the association between genes on JAK-STAT pathway (IFIH1, TYK2, IL-10) and systemic lupus erythematosus: a meta-analysis
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1858-0
Abstract: Previous studies have reported that genes relating to JAK-STAT pathway (IFIH1, TYK2 and IL-10) conferred the susceptibility to SLE. In this study, we performed a meta-analysis (including 43 studies) to evaluate the association between IFIH1… read more here.
Keywords: ifih1; stat pathway; sle; jak stat ... See more keywords
Steroidogenic genes expressions are repressed by high levels of leptin and the JAK/STAT signaling pathway in MA-10 Leydig cells
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-017-3017-x
Abstract: The adipose tissue is an important endocrine organ secreting numerous peptide hormones, including leptin. Increased circulating levels of leptin, as a result of hormonal resistance in obese individuals, may contribute to lower androgen production in… read more here.
Keywords: levels leptin; high levels; stat signaling; jak stat ... See more keywords
2-Methoxyestradiol inhibits carotid artery intimal hyperplasia induced by balloon injury via inhibiting JAK/STAT axis in rats
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-022-19936-y
Abstract: Intimal hyperplasia (IH) is a common complication of vascular interventional procedures that leads to narrowing of the vessel lumen. 2-Methoxyestradiol (2ME), an estrogen metabolite, has numerous pharmacological actions, including vasoprotective and antiproliferative activities. The present… read more here.
Keywords: balloon injury; intimal hyperplasia; jak stat;
MDA5 against enteric viruses through induction of interferon-like response partially via the JAK-STAT cascade.
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral research"
DOI: 10.1016/j.antiviral.2020.104743
Abstract: Enteric viruses including hepatitis E virus (HEV), human norovirus (HuNV), and rotavirus are causing global health issues. The host interferon (IFN) response constitutes the first-line defense against viral infections. Melanoma Differentiation-Associated protein 5 (MDA5) is… read more here.
Keywords: stat cascade; enteric viruses; jak stat; response ... See more keywords