PKM2 promotes cell metastasis and inhibits autophagy via the JAK/STAT3 pathway in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-04041-w
Abstract: Pyruvate kinase M2 (PKM2) is a member of the pyruvate kinase family. It has been recently reported that PKM2 displays non-metabolic activities. Nevertheless, understanding of the role of PKM2 in hepatocellular carcinoma (HCC) is insufficient.… read more here.
Keywords: pkm2; hcc; jak stat3; stat3 pathway ... See more keywords
WP1066, a small molecule inhibitor of the JAK/STAT3 pathway, inhibits ceramide glucosyltransferase activity.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.115
Abstract: WP1066 is a well-known inhibitor of the JAK/STAT3 signaling pathway. By a screen of known small molecule inhibitors of various enzymes and protein factors, we identified WP1066 as a ceramide glucosyltransferase inhibitor. Ceramide glucosyltransferase catalyzes… read more here.
Keywords: glucosyltransferase; jak stat3; ceramide glucosyltransferase; inhibitor jak ... See more keywords
Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.07.020
Abstract: Colivelin is a neuroprotective humanin family peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. We seek to investigate whether this effect of Colivelin also govern ischemic… read more here.
Keywords: colivelin; neuronal death; jak stat3; stat3 signaling ... See more keywords
The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.06.001
Abstract: Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides… read more here.
Keywords: axis comprehensive; stat3; stat3 axis; jak stat3 ... See more keywords
P38 MAPK, NF-κB, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.1c00317
Abstract: Hand-foot syndrome (HFS) is a major adverse reaction to capecitabine (CAP). The exact pathogenesis of this disease remains unclear. In this study, metabolomics combined with cell RNA sequencing was used to study the mechanisms of… read more here.
Keywords: signaling pathway; stat3 signaling; cap; jak stat3 ... See more keywords
The long non-coding RNA LINC00473 contributes to cell proliferation via JAK-STAT3 signaling pathway by regulating miR-195-5p/SEPT2 axis in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Bioscience Reports"
DOI: 10.1042/bsr20191850
Abstract: Abstract Prostate cancer is a kind of male malignant tumor, which has brought tremendous health threat to men. Prostate cancer is difficult to be cured because of high incidence and metastasis rate. Thereby, it is… read more here.
Keywords: mir 195; cell proliferation; cancer; prostate cancer ... See more keywords
Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration
Sign Up to like & getrecommendations! Published in 2017 at "SPINE"
DOI: 10.1097/brs.0000000000001982
Abstract: Study Design. Laboratory study. Objective. To elucidate the potential involvement of the interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducers and activator of transcription (STAT3) pathway in the development of intervertebral disc (IVD) degeneration. Summary of Background Data.… read more here.
Keywords: stat3 pathway; potential involvement; ivd; jak stat3 ... See more keywords
Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000041
Abstract: Background and Aims: Bile acids trigger a hepatic inflammatory response, causing cholestatic liver injury. Runt-related transcription factor-1 (RUNX1), primarily known as a master modulator in hematopoiesis, plays a pivotal role in mediating inflammatory responses. However,… read more here.
Keywords: cholestasis; runx1; stat3 signaling; acid ... See more keywords
Mesenchymal stem cells-derived IL-6 promotes invasion and metastasis of oral squamous cell carcinoma via JAK-STAT3 signalling.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14617
Abstract: OBJECTIVES Oral squamous cell carcinoma (OSCC) is often diagnosed with cervical lymph node metastasis. Mesenchymal stem cells (MSCs) and interleukin-6 (IL-6) signalling are considered to play important roles in promoting tumour malignancy. The detailed biological… read more here.
Keywords: metastasis; cell carcinoma; squamous cell; jak stat3 ... See more keywords
rs2431697, a Polymorphism of Mir-146a, Is a Precozing Marker of Progression to Secondary Myelofibrosis: New Epigenetic Regulation of Jak/Stat3 Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119221
Abstract: Introduction: Transformation to secondary myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PV) and essential thrombocythemia (ET), the two more indolent Ph-negative myeloproliferative neoplasms (MPN). Once transformed, survival is remarkably shorted.… read more here.
Keywords: mir 146a; speakers bureau; progression; jak stat3 ... See more keywords
JAK/STAT3 regulated global gene expression dynamics during late-stage reprogramming process
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genomics"
DOI: 10.1186/s12864-018-4507-2
Abstract: BackgroundThe generation of induced pluripotent stem cells (iPSCs) has underdefined mechanisms. In addition, leukemia inhibitory factor (LIF) activated Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway is the master regulator for naïve-state pluripotency… read more here.
Keywords: stat3; pluripotency; process; expression ... See more keywords