Molecular modeling studies of pyrrolo[2,3-d]pyrimidin-4-amine derivatives as JAK1 inhibitors based on 3D-QSAR, molecular docking, molecular dynamics (MD) and MM-PBSA calculations
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1714483
Abstract: Abstract Rheumatoid Arthritis (RA) is an autoimmune disease caused by overproduction of pro-inflammatory cytokines. Janus Kinases (JAKs) mediate cytokines signaling through the Janus Kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways. Clinical studies… read more here.
Keywords: docking molecular; rheumatoid arthritis; jak1; molecular docking ... See more keywords
Advances in pharmacotherapy for ulcerative colitis: a focus on JAK1 inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2023.2200931
Abstract: ABSTRACT Introduction Janus kinase (JAK) inhibitors are an emerging class of small-molecule drugs, providing targeted therapy for a variety of diseases, and have made their way into the treatment of armamentarium of ulcerative colitis (UC)… read more here.
Keywords: advances pharmacotherapy; jak1 inhibitors; jak inhibitors; ulcerative colitis ... See more keywords
Upadacitinib Is a Better Choice than Abrocitinib for Patients with Moderate-to-Severe Atopic Dermatitis: An Updated Meta-Analysis
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DOI: 10.1155/2023/9067797
Abstract: Background. Blocking agent for immune cytokine pathways is a novel treatment for atopic dermatitis (AD). Janus kinase (JAK) family is one of the cytoplasmic tyrosine kinases that mediate a variety of cytokines. Eight randomized controlled… read more here.
Keywords: moderate severe; abrocitinib; jak1 inhibitors; atopic dermatitis ... See more keywords
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of Asthma
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DOI: 10.2147/dddt.s354291
Abstract: Purpose Janus kinase 1 (JAK1) is implicated in multiple inflammatory pathways that are critical for the pathogenesis of asthma, including the interleukin (IL)-4, IL-5, IL-13, and thymic stromal lymphopoietin cytokine signaling pathways, which have previously… read more here.
Keywords: azd0449 azd4604; jak1; lung; jak1 inhibitors ... See more keywords
In silico Studies of Potential Drug-like Compounds from various Medicinal Plants: The Discovery of JAK1 Inhibitors and JAK3 Inhibitors
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DOI: 10.52711/0974-360x.2023.00194
Abstract: Allergic asthma is a chronic respiratory disease mediated by immunoglobulin E (IgE) and T helper type 2 (Th2) cells. Janus kinase 1 (JAK1) and JAK3, which are interleukin-4 signaling components, are crucial in Th2 cell… read more here.
Keywords: jak3 inhibitors; inhibitors jak3; jak1 inhibitors; medicinal plants ... See more keywords