Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
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DOI: 10.1158/2159-8290.cd-16-1223
Abstract: Loss-of-function mutations in JAK1/2 can lead to acquired resistance to anti-programmed death protein 1 (PD-1) therapy. We reasoned that they may also be involved in primary resistance to anti-PD-1 therapy. JAK1/2-inactivating mutations were noted in… read more here.
Keywords: blockade; primary resistance; jak1 mutations; resistance ... See more keywords
Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1
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DOI: 10.1186/s13073-017-0434-0
Abstract: BackgroundApproximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations—the microsatellite instability (MSI) phenotype. We investigated molecular heterogeneity and tumor immunogenicity in relation to clinical… read more here.
Keywords: multilevel genomics; jak1 mutations; microsatellite instability; colorectal cancers ... See more keywords