Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1.
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DOI: 10.1021/acs.jmedchem.3c00050
Abstract: Developing selective inhibitors for Janus kinase 1 (JAK1) is a significant focus for improving the efficacy and alleviating the adverse effects in treating immune-inflammatory diseases. Herein, we report the discovery of a series of C-5… read more here.
Keywords: pyrazole; inhibitors janus; selective inhibitors; discovery pyrazole ... See more keywords