JAK1 Kinase Activity Is Required for the Dysregulated JAK1-STAT Pathway to Exacerbate Aberrant Protein Aggregation
Sign Up to like & getrecommendations! Published in 2025 at "Physiology"
DOI: 10.1152/physiol.2025.40.s1.1836
Abstract: Background: Intracellular aberrant protein aggregation (APA) is a hallmark of many forms of human disease. No clinical strategies purposely target APA yet. In a recent study, we have discovered that APA hijacks phosphorylated STATs into… read more here.
Keywords: physiology; jak1 cko; jak1 stat; jak1 kinase ... See more keywords