HDAC3 Downregulation Improves Cerebral Ischemic Injury via Regulation of the SDC1-Dependent JAK1/STAT3 Signaling Pathway Through miR-19a Upregulation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02325-w
Abstract: Histone deacetylase (HDAC) inhibitors can protect the brain from ischemic injury. This study aimed to identify the regulation of HDAC3 in cerebral ischemic injury. Middle cerebral artery occlusion (MCAO) was performed to establish a mouse… read more here.
Keywords: ischemic injury; jak1 stat3; mir 19a; hdac3 ... See more keywords
C-terminal of E1A binding protein 2 promotes the malignancy of osteosarcoma cells via JAK1/Stat3 signaling
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Communication and Signaling"
DOI: 10.1007/s12079-019-00523-9
Abstract: Previous studies have demonstrated that the C-terminal of E1A binding proteins (CtBPs) influences tumorigenesis by participating in cell signal transduction in various human malignancies. However, the detailed expression patterns of CtBP isoforms in human osteosarcoma… read more here.
Keywords: ctbp2; expression; jak1 stat3; cell ... See more keywords
Berberinesuppresses bladdercancercell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114575
Abstract: Hyperactivation of signal transducer and activator of transcription 3 (STAT3) is strongly associated with cancer initiation, progression, metastasis, chemoresistance, and immune evasion; thus, STAT3 has beenintenselystudiedasatherapeutictargetfor cancer treatment. Berberine (BBR), an active component extracted from… read more here.
Keywords: upregulation mir; jak1 stat3; stat3; stat3 signaling ... See more keywords
Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Cancer"
DOI: 10.1038/s41416-019-0640-1
Abstract: Background Although produced by several types of tumours, the role of serotonin on cancer biology is yet to be understood. Methods The effects of serotonin (5-HT) on human breast cancer cells proliferation, signalling pathways and… read more here.
Keywords: breast cancer; cancer cells; cancer; jak1 stat3 ... See more keywords
Implication of JAK1/STAT3/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64050-z
Abstract: Aging causes morphological and functional changes in the cerebellum. This work aimed to demonstrate the implication of JAK1/STAT3/SOCS3 on aging–induced changes of rat cerebellum. Thirty male rats were divided into: adult (12 months), early senile… read more here.
Keywords: late senile; stat3; cerebellum; jak1 stat3 ... See more keywords
Hepatoprotective effect of rebamipide against methotrexate-induced hepatic intoxication: role of Nrf2/GSK-3β, NF-κβ-p65/JAK1/STAT3, and PUMA/Bax/Bcl-2 signaling pathways
Sign Up to like & getrecommendations! Published in 2020 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2020.1811307
Abstract: Abstract Objectives The fact that methotrexate (MTX) is hepatotoxic is an important reason to limit its clinical use. Rebamipide (REB) has antioxidant and anti-inflammatory properties and is useful for the treatment of gastro-duodenal ulcers. This… read more here.
Keywords: puma bax; group; stat3 puma; mtx ... See more keywords
lncRNA MSC-AS1/miRNA-429 Axis Mediates Growth and Metastasis of Nasopharyngeal Carcinoma via JAK1/STAT3 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/1447207
Abstract: Objective We attempted to clarify the effect of lncRNA MSC-AS1 on carcinogenic and development of nasopharyngeal carcinoma (NPC) and the related mechanisms. Methods The levels of MSC-AS1 and miR-429 were estimated in NPC tissues and… read more here.
Keywords: growth; jak1 stat3; msc as1; mir 429 ... See more keywords
The interplay between HIF-1α and long noncoding GAS5 regulates the JAK1/STAT3 signalling pathway in hypoxia-induced injury in myocardial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular diagnosis and therapy"
DOI: 10.21037/cdt-20-773
Abstract: Background Long non-coding RNA (lncRNA) GAS5 is associated with hypoxia-induced diseases whereas hypoxia-inducible factor-1α (HIF-1α) plays an important role in hypoxic injury of cells. The current study explores the regulatory functions of GAS5/HIF-1α which co-play… read more here.
Keywords: cell viability; hif; gas5 hif; hypoxia ... See more keywords
Raspberry ketone glucoside suppresses melanin synthesis through IL6/JAK1/STAT3 signal pathway.
Sign Up to like & getrecommendations! Published in 2023 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202305_32336
Abstract: OBJECTIVE This study aimed to evaluate the anti-melanogenic activity of raspberry ketone glucoside (RKG) and further explore the specific molecular mechanisms by which RKG affects melanogenesis. MATERIALS AND METHODS The B16F10 cells model, the mushroom… read more here.
Keywords: stat3 signal; jak1 stat3; melanogenesis; pathway ... See more keywords
Lipophilic Constituents in Salvia miltiorrhiza Inhibit Activation of the Hepatic Stellate Cells by Suppressing the JAK1/STAT3 Signaling Pathway: A Network Pharmacology Study and Experimental Validation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.770344
Abstract: Liver fibrosis is currently a global health challenge with no approved therapy, with the activation of hepatic stellate cells being a principal factor. Lipophilic constituents in Salvia miltiorrhiza (LS) have been reported to improve liver… read more here.
Keywords: stellate cells; liver fibrosis; signaling pathway; pharmacology ... See more keywords
Candesartan Attenuates Cisplatin-Induced Lung Injury by Modulating Oxidative Stress, Inflammation, and TLR-4/NF-κB, JAK1/STAT3, and Nrf2/HO-1 Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15101222
Abstract: Cisplatin (CIS) is an effective chemotherapeutic agent against different cancers. The use of CIS is associated with acute lung injury (ALI) and other adverse effects, and oxidative stress and inflammation were implicated in its toxic… read more here.
Keywords: lung injury; oxidative stress; jak1 stat3; stress inflammation ... See more keywords