The JAK Inhibitor Tofacitinib Inhibits Structural Damage in Osteoarthritis by Modulating JAK1/TNF-alpha/IL-6 Signaling Through Mir-149-5p.
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DOI: 10.1016/j.bone.2021.116024
Abstract: BACKGROUND Osteoarthritis (OA), a common articular bone degenerative disease, is exacerbated by proinflammatory cytokine signaling. Mounting evidence suggests that epigenetic modifiers, namely microRNAs (miRs), are dysregulated in articular chondrocytes (ACs) during OA. METHODS An initial… read more here.
Keywords: tofacitinib; jak1 tnf; expression; mir 149 ... See more keywords