Platelets from Calreticulin mutated essential thrombocythemia patients are less reactive than JAK2 V617F mutated platelets
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25713
Abstract: Both JAK2V617F and calreticulin (CALR) mutated essential thrombocythemia (ET) patients have different clinical characteristics, with lower thrombosis risk in patients with CALR mutations. To elucidate the mechanism for this lower risk we studied platelet function… read more here.
Keywords: calr mutated; mutated platelets; platelet; mutated essential ... See more keywords
PD‐L1 overexpression correlates with JAK2‐V617F mutational burden and is associated with 9p uniparental disomy in myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26461
Abstract: Myeloproliferative neoplasms (MPN) are chronic stem cell disorders characterized by enhanced proliferation of myeloid cells, immune deregulation, and drug resistance. JAK2 somatic mutations drive the disease in 50–60% and CALR mutations in 25–30% of cases.… read more here.
Keywords: jak2; v617f mutational; jak2 v617f; myeloproliferative neoplasms ... See more keywords
Computational modelling and invitro evaluation identified natural product - Z218 as a novel Janus Kinase-2 (JAK2) inhibitor to combat Beta Thalassemia.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2459
Abstract: Aberrant activity of Janus kinase 2 (JAK2) is a known driver of several myeloproliferative disorders, including polycythemia Vera, and Thalassemia. Several inhibitors have been proposed to inhibit JAK2 activity in order to control the disease… read more here.
Keywords: kinase jak2; kinase; jak2; natural product ... See more keywords
Exercise preconditioning attenuates cerebral ischemia-induced neuronal apoptosis, Th17/Treg imbalance, and inflammation in rats by inhibiting the JAK2/STAT3 pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Brain and behavior"
DOI: 10.1002/brb3.3030
Abstract: BACKGROUND Exercise preconditioning (EP) is essential for preventing ischemic stroke. Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia-reperfusion injury model. Nonetheless, there have been few reports on the relationship between… read more here.
Keywords: th17 treg; jak2 stat3; group; jak2 ... See more keywords
Concomitant and noncanonical JAK2 and MPL mutations in JAK2V617F‐ and MPLW515 L‐positive myelofibrosis
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22781
Abstract: Sequential genotyping for phenotype‐driver mutations in JAK2 (exon 14), CALR (exon 9), and MPL (exon 10) is recommended in patients with myeloproliferative neoplasms. Yet, atypical JAK2‐ and MPL‐mutations were described in some triple‐negative patients. Whether… read more here.
Keywords: mpl mutations; jak2 mpl; noncanonical jak2; mpl ... See more keywords
Late‐Onset Chorea in JAK2‐Associated Essential Thrombocythemia
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DOI: 10.1002/mdc3.13105
Abstract: Somatic mutations in JAK2 are associated with chronic myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF). The most common variant, Val617Phe (JAK2), accounts for >95% of polycythemia vera and 50%–60% of… read more here.
Keywords: late onset; jak2 associated; polycythemia vera; essential thrombocythemia ... See more keywords
Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23818
Abstract: Fibroblast-like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of… read more here.
Keywords: socs3 jak2; inflammatory response; jak2; jak2 stat3 ... See more keywords
Combined PD-1 and JAK1/2 inhibition in refractory primary mediastinal B-cell lymphoma
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DOI: 10.1007/s00277-018-3233-9
Abstract: Dear Editor, Primarymediastinal large B-cell lymphoma (PMBL) represents 2–4% of all B-cell non-Hodgkin lymphoma [1]. It shares clinical and molecular features with classical Hodgkin lymphoma [2]. Amplification or gain of 9p24.1 is observed in more… read more here.
Keywords: lymphoma; pmbl; cell lymphoma; refractory ... See more keywords
International external quality assurance of JAK2 V617F quantification
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DOI: 10.1007/s00277-018-3570-8
Abstract: External quality assurance (EQA) programs are vital to ensure high quality and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation in methodology. Results cannot be… read more here.
Keywords: jak2 v617f; jak2; external quality; quantification ... See more keywords
Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model
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DOI: 10.1007/s10637-022-01212-y
Abstract: Background. Myeloproliferative neoplasms (MPN) are disorders characterized by an alteration at the hematopoietic stem cell (HSC) level, where the JAK2 mutation is the most common genetic alteration found in classic MPN (polycythemia vera, essential thrombocythemia,… read more here.
Keywords: jak2; jak2 v617f; phenformin; early hematopoietic ... See more keywords
Effect of electroacupuncture on JAK2/STAT3 pathway in synovial tissues of rats with rheumatoid arthritis
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DOI: 10.1007/s11726-019-1121-z
Abstract: To observe the effect of electroacupuncture (EA) on Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway in knee joint synovial tissues of rats with rheumatoid arthritis (RA) and to explore the action… read more here.
Keywords: jak2 stat3; stat3 pathway; group; drug group ... See more keywords