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   Articles with "jak2" as a keyword



MicroRNA‐204‐5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202403080

Abstract: Major depressive disorder (MDD) is usually considered associate with immune inflammation and synaptic injury within specific brain regions. However, the molecular mechanisms underlying the neural deterioration resulting in depression remain unclear. Here, it is found… read more here.

Keywords: jak2 stat3; stat3 signaling; jak2; mir 204 ... See more keywords

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2-Mutant Leukemias.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202515127

Abstract: The JAK2-V617F mutation is the most common genetic alteration in myeloproliferative neoplasms (MPN), which can progress to secondary acute myeloid leukemia (sAML), a chemotherapy-resistant disease with limited treatment options and a poor prognosis. Although the… read more here.

Keywords: targeting desi2; jak2 mutant; jak2; jak2 v617f ... See more keywords

Platelets from Calreticulin mutated essential thrombocythemia patients are less reactive than JAK2 V617F mutated platelets

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recommendations! Published in 2019 at "American Journal of Hematology"

DOI: 10.1002/ajh.25713

Abstract: Both JAK2V617F and calreticulin (CALR) mutated essential thrombocythemia (ET) patients have different clinical characteristics, with lower thrombosis risk in patients with CALR mutations. To elucidate the mechanism for this lower risk we studied platelet function… read more here.

Keywords: calr mutated; mutated platelets; platelet; mutated essential ... See more keywords

PD‐L1 overexpression correlates with JAK2‐V617F mutational burden and is associated with 9p uniparental disomy in myeloproliferative neoplasms

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recommendations! Published in 2022 at "American Journal of Hematology"

DOI: 10.1002/ajh.26461

Abstract: Myeloproliferative neoplasms (MPN) are chronic stem cell disorders characterized by enhanced proliferation of myeloid cells, immune deregulation, and drug resistance. JAK2 somatic mutations drive the disease in 50–60% and CALR mutations in 25–30% of cases.… read more here.

Keywords: jak2; v617f mutational; jak2 v617f; myeloproliferative neoplasms ... See more keywords

Computational modelling and invitro evaluation identified natural product - Z218 as a novel Janus Kinase-2 (JAK2) inhibitor to combat Beta Thalassemia.

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recommendations! Published in 2023 at "Biotechnology and applied biochemistry"

DOI: 10.1002/bab.2459

Abstract: Aberrant activity of Janus kinase 2 (JAK2) is a known driver of several myeloproliferative disorders, including polycythemia Vera, and Thalassemia. Several inhibitors have been proposed to inhibit JAK2 activity in order to control the disease… read more here.

Keywords: kinase jak2; kinase; jak2; natural product ... See more keywords

Exercise preconditioning attenuates cerebral ischemia-induced neuronal apoptosis, Th17/Treg imbalance, and inflammation in rats by inhibiting the JAK2/STAT3 pathway.

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recommendations! Published in 2023 at "Brain and behavior"

DOI: 10.1002/brb3.3030

Abstract: BACKGROUND Exercise preconditioning (EP) is essential for preventing ischemic stroke. Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia-reperfusion injury model. Nonetheless, there have been few reports on the relationship between… read more here.

Keywords: th17 treg; jak2 stat3; group; jak2 ... See more keywords

Concomitant and noncanonical JAK2 and MPL mutations in JAK2V617F‐ and MPLW515 L‐positive myelofibrosis

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recommendations! Published in 2019 at "Genes"

DOI: 10.1002/gcc.22781

Abstract: Sequential genotyping for phenotype‐driver mutations in JAK2 (exon 14), CALR (exon 9), and MPL (exon 10) is recommended in patients with myeloproliferative neoplasms. Yet, atypical JAK2‐ and MPL‐mutations were described in some triple‐negative patients. Whether… read more here.

Keywords: mpl mutations; jak2 mpl; noncanonical jak2; mpl ... See more keywords

TLE3 Is a Novel Fusion Partner of JAK2 in Myeloid/Lymphoid Neoplasm With Eosinophilia Responding to JAK2 Inhibition

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recommendations! Published in 2024 at "Genes"

DOI: 10.1002/gcc.23261

Abstract: Chromosomal rearrangements involving Janus kinase 2 (JAK2) are rare but recurrent findings in lymphoid or myeloid neoplasia. Detection of JAK2 fusion genes is important as patients with aberrantly activated JAK2 may benefit from treatment with… read more here.

Keywords: partner jak2; novel fusion; tle3 novel; fusion ... See more keywords
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Late‐Onset Chorea in JAK2‐Associated Essential Thrombocythemia

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recommendations! Published in 2021 at "Movement Disorders Clinical Practice"

DOI: 10.1002/mdc3.13105

Abstract: Somatic mutations in JAK2 are associated with chronic myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis (PMF). The most common variant, Val617Phe (JAK2), accounts for >95% of polycythemia vera and 50%–60% of… read more here.

Keywords: late onset; jak2 associated; polycythemia vera; essential thrombocythemia ... See more keywords

Isoferulic Acid Mitigates Acute Lung Injury Induced by Sepsis Through the Inhibition of JAK2

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.8526

Abstract: Sepsis‐induced acute lung injury (ALI), among the most severe organ damages, induces irreversible lung injuries and results in a high mortality rate. The occurrence of ALI is highly correlated with the out‐of‐control inflammatory factors. Therefore,… read more here.

Keywords: pharmacology; jak2; lung injury; ifa ... See more keywords

Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation.

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recommendations! Published in 2023 at "Environmental toxicology"

DOI: 10.1002/tox.23818

Abstract: Fibroblast-like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of… read more here.

Keywords: socs3 jak2; inflammatory response; jak2; jak2 stat3 ... See more keywords