Not so exclusive: Co-mutations in JAK2, MPL and CALR define distinct hematologic and clonal signatures
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DOI: 10.1182/blood-2025-3815
Abstract: Background: The canonical driver mutations in JAK2, CALR, and MPL are typically regarded as mutually exclusive in myeloproliferative neoplasms (MPNs). However, co-occurrence is increasingly recognized, raising questions about their clinical and clonal implications. Such co-mutations… read more here.
Keywords: jak2 calr; calr; mpl; calr mpl ... See more keywords
JAK2, CALR, MPL and ASXL1 mutational status correlates with distinct histological features in Philadelphia chromosome-negative myeloproliferative neoplasms
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DOI: 10.3324/haematol.2017.178988
Abstract: Philadelphia chromosome (Ph)-negative myeloproliferative neoplasms (MPN) [essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF)] vary in morphological features, disease presentation, and, most importantly, clinical outcome.[1][1] The World Health Organization (WHO) read more here.
Keywords: negative myeloproliferative; jak2 calr; philadelphia chromosome; myeloproliferative neoplasms ... See more keywords