Discovery of 4-piperazinyl-2-aminopyrimidine derivatives as dual inhibitors of JAK2 and FLT3.
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DOI: 10.1016/j.ejmech.2019.111590
Abstract: Hybridization strategy is an effective strategy to obtain multi-target inhibitors in drug design. In this study, we assembled the pharmacophores of momelotinib and tandutinib to get a series of 4-piperazinyl-2-aminopyrimidine derivatives. All compounds were tested… read more here.
Keywords: piperazinyl aminopyrimidine; aminopyrimidine derivatives; jak2 flt3; flt3 ... See more keywords