Discovery of JAK2/3 Inhibitors from Quinoxalinone-Containing Compounds
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04769
Abstract: Janus kinases (JAKs) are involved in a wide variety of cell signaling associated with T-cell and B-cell mediated diseases. The pathogenesis of common lymphoid-derived diseases and leukemia cancer has been implicated in JAK2 and JAK3.… read more here.
Keywords: cell; discovery jak2; jak2 inhibitors; inhibitors quinoxalinone ... See more keywords
JAK2 inhibitors for myeloproliferative neoplasms: what is next?
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-742288
Abstract: Since its approval in 2011, the Janus kinase 1/2 (JAK1/2) inhibitor ruxolitinib has evolved to become the centerpiece of therapy for myelofibrosis (MF), and its use in patients with hydroxyurea resistant or intolerant polycythemia vera… read more here.
Keywords: inhibitors myeloproliferative; ruxolitinib; jak2 inhibitors; myeloproliferative neoplasms ... See more keywords
Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
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DOI: 10.1371/journal.pone.0222944
Abstract: Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling is critical to multiple cellular processes, including survival, differentiation, and proliferation. JAK-STAT signaling dysregulation has been noted in inflammatory disorders, and aberrant JAK2 pathway activation has… read more here.
Keywords: pacritinib; momelotinib pacritinib; jak2 inhibitors; momelotinib ... See more keywords
IRF7 expression correlates with HIV latency reversal upon specific blockade of immune activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1001068
Abstract: The persistence of latent HIV reservoirs allows for viral rebound upon antiretroviral therapy interruption, hindering effective HIV-1 cure. Emerging evidence suggests that modulation of innate immune stimulation could impact viral latency and contribute to the… read more here.
Keywords: irf7 expression; jak2 inhibitors; expression; blockade ... See more keywords
In silico multiscale drug design to discover key structural features of potential JAK2 inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0124
Abstract: Background: JAK2 inhibitors have been proposed as a new therapeutic option for thalassemia therapy. The objective of this study was to discover the key structural features for improving 2-aminopyrimidine derivatives as potential JAK2 inhibitors. Materials… read more here.
Keywords: key structural; jak2 inhibitors; discover key; jak2 ... See more keywords