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   Articles with "jak2 mpl" as a keyword



Concomitant and noncanonical JAK2 and MPL mutations in JAK2V617F‐ and MPLW515 L‐positive myelofibrosis

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recommendations! Published in 2019 at "Genes"

DOI: 10.1002/gcc.22781

Abstract: Sequential genotyping for phenotype‐driver mutations in JAK2 (exon 14), CALR (exon 9), and MPL (exon 10) is recommended in patients with myeloproliferative neoplasms. Yet, atypical JAK2‐ and MPL‐mutations were described in some triple‐negative patients. Whether… read more here.

Keywords: mpl mutations; jak2 mpl; noncanonical jak2; mpl ... See more keywords

Outcomes of Blast-Phase MPN and JAK2, MPL, and CALR Mutated de Novo AML Compared to AML with Wild-Type JAK2, MPL, and CALR Genes: A Propensity Score-Adjusted Cohort Study

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-207748

Abstract: Background: The BCR-ABL-negative myeloproliferative neoplasms (MPNs) include polycythemia vera, essential thrombocythemia, and primary myelofibrosis. These MPNs are clonal disorders of hematopoietic stem cells that can transform into secondary acute myeloid leukemia (AML), known as the… read more here.

Keywords: jak2 mpl; aml; mpl calr;

Not so exclusive: Co-mutations in JAK2, MPL and CALR define distinct hematologic and clonal signatures

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-3815

Abstract: Background: The canonical driver mutations in JAK2, CALR, and MPL are typically regarded as mutually exclusive in myeloproliferative neoplasms (MPNs). However, co-occurrence is increasingly recognized, raising questions about their clinical and clonal implications. Such co-mutations… read more here.

Keywords: jak2 calr; calr; mpl; calr mpl ... See more keywords

Calr Vs. JAK2 Vs. MPL Mutations in the Progression of Philadelphia-Negative Myeloproliferative Neoplasms

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood.v130.suppl_1.5283.5283

Abstract: Objective: Myeloproliferative neoplasms (MPNs) are clonal hematopoietic disorders characterized by proliferation in one or more myeloid lineages. The classical Philadelphia (Ph) chromosome-negative MPN includes polycythemia vera (PV), essential thrombocytosis (ET), and primary myelofibrosis (PMF). All… read more here.

Keywords: jak2 mpl; mpn; pmf patients; calr jak2 ... See more keywords