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   Articles with "jak2 mutant" as a keyword



Targeting DESI2 as a Novel Therapeutic Strategy for JAK2-Mutant Leukemias.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202515127

Abstract: The JAK2-V617F mutation is the most common genetic alteration in myeloproliferative neoplasms (MPN), which can progress to secondary acute myeloid leukemia (sAML), a chemotherapy-resistant disease with limited treatment options and a poor prognosis. Although the… read more here.

Keywords: targeting desi2; jak2 mutant; jak2; jak2 v617f ... See more keywords

Spatial transcriptomic dissection of the myeloproliferative neoplasm niche uncovers mutant clone interactions and microenvironmental rewiring

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-3761

Abstract: The development of myeloid neoplasms involves complex cell-cell communication and functional changes within the bone marrow niche. Current NGS techniques, such as scRNA-seq, capture transcriptomic changes at the single-cell level but fail to reveal cell-cell… read more here.

Keywords: analysis; cell; mutant cells; jak2 mutant ... See more keywords

Interleukin-12 and TNFα signaling drives parallel evolution of independent leukemic clones in JAK2V617F mutant myeloproliferative neoplasms

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recommendations! Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-5538

Abstract: Progression from chronic phase myeloproliferative neoplasm (MPN) to secondary acute myeloid leukemia (sAML) is a poorly understood, severe complication traditionally linked to additional mutations in the MPN driver clone in genes such as TET2 and… read more here.

Keywords: jak2 mutant; tnf; jak2; tet2 mutant ... See more keywords

Iron is a modifier of the phenotypes of JAK2-mutant myeloproliferative neoplasms.

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recommendations! Published in 2023 at "Blood"

DOI: 10.1182/blood.2022017976

Abstract: JAK2-V617F mutation causes myeloproliferative neoplasms (MPN) that can manifest as polycythemia vera (PV), essential thrombocythemia (ET) or primary myelofibrosis (PMF). PV patients at diagnosis already exhibited iron deficiency, whereas ET patients had normal iron stores.… read more here.

Keywords: iron; jak2 mutant; jak2; mice ... See more keywords