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   Articles with "jak2 signaling" as a keyword



TARGETING MYD88-JAK2 SIGNALING IN ABERRANTLY DIFFERENTIATED MESENCHYMAL PROGENITORS IN ULCERATIVE COLITIS

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recommendations! Published in 2025 at "Gastroenterology"

DOI: 10.1053/j.gastro.2025.01.064

Abstract: Three novel therapies have shown promise in managing moderate-to-severe ulcerative colitis (UC): fecal microbiota transplantation (FMT), mesenchymal stem cell (MSC) therapy, and targeting the JAK/STAT signaling pathway. Individually, these treatment approaches face issues with either… read more here.

Keywords: jak2 signaling; therapy; jak2; ulcerative colitis ... See more keywords

Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling

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recommendations! Published in 2024 at "Science Advances"

DOI: 10.1126/sciadv.adl2097

Abstract: Janus kinase 2 (JAK2) mediates type I/II cytokine receptor signaling, but JAK2 is also activated by somatic mutations that cause hematological malignancies by mechanisms that are still incompletely understood. Quantitative superresolution microscopy (qSMLM) showed that… read more here.

Keywords: jak2 signaling; receptor; pathogenic jak2; jak2 ... See more keywords
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Coniferyl Aldehyde Inhibits the Inflammatory Effects of Leptomeningeal Cells by Suppressing the JAK2 Signaling

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recommendations! Published in 2020 at "BioMed Research International"

DOI: 10.1155/2020/4616308

Abstract: Background The brain is in many ways an immunologically and pharmacologically privileged site because of the blood-brain barrier (BBB). But for chronic peripheral inflammation, inflammatory signals can be transmitted from the peripheral system into the… read more here.

Keywords: jak2; coniferyl aldehyde; jak2 signaling; suppressing jak2 ... See more keywords

Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma.

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recommendations! Published in 2021 at "Haematologica"

DOI: 10.3324/haematol.2020.274506

Abstract: Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECyTCL) is a rare variant of cutaneous T-cell lymphoma with an aggressive clinical course and a very poor prognosis. Until now, neither a systematic characterization of genetic… read more here.

Keywords: cutaneous cd8; jak2; jak2 signaling; primary cutaneous ... See more keywords

PDGF-BB promotes the differentiation and proliferation of MC3T3-E1 cells through the Src/JAK2 signaling pathway

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recommendations! Published in 2018 at "Molecular Medicine Reports"

DOI: 10.3892/mmr.2018.9351

Abstract: Platelet-derived growth factor-BB (PDGF-BB) serves a critical function in human osteoblast differentiation and proliferation. Src and Janus kinase 2 (JAK2) are involved in these processes. In our previous study, it was identified that Src could… read more here.

Keywords: jak2 signaling; src jak2; signaling pathway; differentiation proliferation ... See more keywords