JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis
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DOI: 10.3389/fimmu.2021.734652
Abstract: Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known. In this study, we perform… read more here.
Keywords: first encounter; bacterial endotoxins; jak2 stat; tolerized genes ... See more keywords