Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.06.009
Abstract: ABSTRACT Acute intracerebral hemorrhage (ICH) complicated by hyperglycemia is associated with aggravation of post‐stroke inflammation, leading to exacerbation of brain edema and predicting poor neurological outcomes and higher mortality of patients. Osteopontin (OPN) is a… read more here.
Keywords: brain edema; inflammation; jak2 stat1; hyperglycemic rats ... See more keywords
JAK2/STAT1-mediated HMGB1 translocation increases inflammation and cell death in a ventilator-induced lung injury model
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0308-8
Abstract: Janus kinase 2/signal transducer and activators of transcription 1 (JAK2/STAT1) signaling is a common pathway that contributes to numerous inflammatory disorders, including different forms of acute lung injury (ALI). However, the role of JAK2/STAT1 in… read more here.
Keywords: lung injury; hmgb1 translocation; jak2 stat1; jak2 ... See more keywords
Lac water extract inhibits IFN-γ signaling through JAK2-STAT1-IRF1 axis in human melanoma
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DOI: 10.1039/c8ra02955e
Abstract: Interferon-γ (IFN-γ) is a cytokine that plays an important role in the host defense of infectious diseases and in immune surveillance during tumor development; however, it has adverse effects in the pathogenesis of autoimmune diseases… read more here.
Keywords: water extract; stat1 irf1; lac water; ifn signaling ... See more keywords
Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the JAK2/STAT1/3/ALDH1A3 Pathway
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DOI: 10.3390/biomedicines9080885
Abstract: Cholangiocarcinoma is the most common primary malignant tumor of the bile duct. The current standard first-line treatment for advanced or metastatic cholangiocarcinoma is gemcitabine and cisplatin. However, few effective treatment choices exist for refractory cholangiocarcinoma,… read more here.
Keywords: jak2 stat1; cholangiocarcinoma; combined gemcitabine;