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   Articles with "jak2 stat3" as a keyword



MicroRNA‐204‐5p Deficiency within the vmPFC Region Contributes to Neuroinflammation and Behavioral Disorders via the JAK2/STAT3 Signaling Pathway in Rats

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202403080

Abstract: Major depressive disorder (MDD) is usually considered associate with immune inflammation and synaptic injury within specific brain regions. However, the molecular mechanisms underlying the neural deterioration resulting in depression remain unclear. Here, it is found… read more here.

Keywords: jak2 stat3; stat3 signaling; jak2; mir 204 ... See more keywords

Exercise preconditioning attenuates cerebral ischemia-induced neuronal apoptosis, Th17/Treg imbalance, and inflammation in rats by inhibiting the JAK2/STAT3 pathway.

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recommendations! Published in 2023 at "Brain and behavior"

DOI: 10.1002/brb3.3030

Abstract: BACKGROUND Exercise preconditioning (EP) is essential for preventing ischemic stroke. Recent studies have shown that EP exerts neuroprotective effects in the cerebral ischemia-reperfusion injury model. Nonetheless, there have been few reports on the relationship between… read more here.

Keywords: th17 treg; jak2 stat3; group; jak2 ... See more keywords

Ticagrelor reduces myocardial cell injury induced by myocardial ischemia-reperfusion in diabetic rats by activating JAK2/STAT3.

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recommendations! Published in 2022 at "Cell biology international"

DOI: 10.1002/cbin.11940

Abstract: The treatment of diabetic patients with myocardial infarction is still full of challenges. Diabetes may exacerbate myocardial ischemia/reperfusion (I/R) injury. Ticagrelor alleviates I/R injury. However, the protective effects of ticagrelor on the diabetic myocardium following… read more here.

Keywords: diabetic rats; ticagrelor; myocardial ischemia; jak2 stat3 ... See more keywords

HIF‐1α facilitates osteocyte‐mediated osteoclastogenesis by activating JAK2/STAT3 pathway in vitro

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.28721

Abstract: Osteocytes, entrapped within the mineralized bone matrix, has been found to have numerous functions such as acting as an orchestrator of bone remodeling through regulation of both osteoclast and osteoblast activity and also functioning as… read more here.

Keywords: hif; jak2 stat3; rankl; stat3 pathway ... See more keywords

Inhibition of JAK2/STAT3 reduces tumor‐induced angiogenesis and myeloid‐derived suppressor cells in head and neck cancer

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recommendations! Published in 2018 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.22767

Abstract: Angiogenesis is an essential event in tumor growth and metastasis, and immune system also contributes to the tumor evasion. Emerging evidences have suggested the bidirectional link between angiogenesis and immunosuppression. Myeloid‐derived suppressor cell (MDSC) is… read more here.

Keywords: hnscc; jak2 stat3; angiogenesis; tumor ... See more keywords

CircTCF25 serves as a sponge for miR‐206 to support proliferation, migration, and invasion of glioma via the Jak2/p‐Stat3/CypB axis

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recommendations! Published in 2022 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23402

Abstract: Glioma is the most common primary malignant intracranial tumor in humans, and glioblastoma (GBM) has been associated with a more aggressive histology and poorer prognosis. There is growing evidence that circular RNAs (circRNAs) are involved… read more here.

Keywords: cypb; migration invasion; jak2 stat3; circtcf25 ... See more keywords
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Scutellarin Attenuates Lipopolysaccharide‐Induced Acute Lung Injury in Mice by Inhibiting M1 Macrophage Polarization via the GBP2/JAK2/STAT3 Signaling Pathway

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.70099

Abstract: Uncontrolled inflammation and excessive M1 macrophage polarization are key drivers of acute lung injury (ALI). Scutellarin (SCU), a natural flavonoid compound, possesses anti‐inflammatory activity, but its precise mechanism remains unclear. This study aimed to investigate… read more here.

Keywords: jak2 stat3; macrophage polarization; lung injury; gbp2 ... See more keywords

Mangiferin prevents hepatocyte epithelial‐mesenchymal transition in liver fibrosis via targeting HSP27‐mediated JAK2/STAT3 and TGF‐β1/Smad pathway

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7549

Abstract: Hepatocytes has been confirmed to undergo EMT and can be converted into myofibroblasts during hepatic fibrogenesis. However, the mechanism of hepatocyte EMT regulation in hepatic fibrosis, particularly through HSP27 (human homologue of rodent HSP25), remains… read more here.

Keywords: liver fibrosis; hsp27; tgf smad; jak2 stat3 ... See more keywords

Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation.

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recommendations! Published in 2023 at "Environmental toxicology"

DOI: 10.1002/tox.23818

Abstract: Fibroblast-like synoviocytes accumulation, proliferation and activation, and the subsequent inflammatory mediators production play a key role in the progression of rheumatoid arthritis (RA). It is well established that Janus kinase 2/signal transducer and activator of… read more here.

Keywords: socs3 jak2; inflammatory response; jak2; jak2 stat3 ... See more keywords

Anlotinib combined with temozolomide suppresses glioblastoma growth via mediation of JAK2/STAT3 signaling pathway

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recommendations! Published in 2022 at "Cancer Chemotherapy and Pharmacology"

DOI: 10.1007/s00280-021-04380-5

Abstract: Anlotinib protects against carcinogenesis through the induction of autophagy and apoptosis. The current study evaluated the role and molecular mechanisms of anlotinib in glioblastoma, and the effects of anlotinib in combination with temozolomide (TMZ). Cell… read more here.

Keywords: vegfa; glioblastoma; growth; signaling pathway ... See more keywords

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway

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recommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-024-05625-5

Abstract: The aim of this study was to investigate the anti-tumor effect of resveratrol (RSV) on glioblastoma (GBM) and its specific mechanism in improving the inflammatory response of the tumor microenvironment. The tumor microenvironment of GBM… read more here.

Keywords: jak2 stat3; gbm; tumor; rsv ... See more keywords