The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma
Sign Up to like & getrecommendations! Published in 2018 at "Veterinary and Comparative Oncology"
DOI: 10.1111/vco.12311
Abstract: BACKGROUND Mastocytoma are frequently diagnosed cutaneous neoplasms in dogs. In non-resectable mastocytoma patients, novel targeted drugs are often applied. The transcription factor STAT5 has been implicated in the survival of human neoplastic mast cells (MC).… read more here.
Keywords: stat5; target; canine mastocytoma; jak2 stat5 ... See more keywords
PRL/PRLR Can Promote Insulin Resistance by Activating the JAK2/STAT5 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/1456187
Abstract: Objective Although prolactin (PRL) is known to affect food intake, weight gain, and insulin resistance, its effects on lipid metabolism and underlying mechanisms remain underinvestigated. This study aimed to investigate the effects of PRL and… read more here.
Keywords: prlr; insulin resistance; stat5; group ... See more keywords
Proteomics reveals that Di Dang decoction can regulate the Jak2/Stat5 signaling pathway and inhibit apoptosis by reducing the oxidative stress response in rats with acute intracerebral hemorrhagic stroke.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4165306
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Di Dang decoction (DDD) is a prescription used for the treatment of cerebral hemorrhage. Its use is derived from the theory of typhoid fever, it has an obvious clinical effect and it has… read more here.
Keywords: jak2 stat5; oxidative stress; stat5; expression ... See more keywords
The Dipeptide Pro-Gly Promotes IGF-1 Expression and Secretion in HepG2 and Female Mice via PepT1-JAK2/STAT5 Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2018.00424
Abstract: It has been shown that IGF-1 secretion is influenced by dietary protein or amino acid. However, whether the dipeptides elicit regulatory effects on IGF-1 secretion remains largely unclear. Thus, this study aimed to investigate the… read more here.
Keywords: secretion; igf expression; jak2 stat5; expression secretion ... See more keywords