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Published in 2017 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-017-1618-1
Abstract: BackgroundEssential thrombocythemia (ET) is a benign disease with slow progress in which thrombosis is a cause of mortality. JAK2V617F and calreticulin (CALR) are the most frequent mutations in this disease. In this systematic review and…
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Keywords:
jak2v617f;
diagnosis;
prognosis;
calr ... See more keywords
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Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.335
Abstract: Myeloproliferative neoplasms (MPN) arise from the acquisition of genetic mutations in hematopoietic stem cells. Currently, patients receive treatment with cytotoxic agents, the JAK1/2 inhibitor, ruxolitinib, or pegylated forms of interferon alpha (IFN-α). Ruxolitinib is highly…
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Keywords:
jak2v617f;
treatment;
stem;
cell ... See more keywords
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Published in 2018 at "Leukemia Research Reports"
DOI: 10.1016/j.lrr.2017.12.002
Abstract: JAK2V617F mutation is found in about 60% of cases of essential thrombocytemia (ET) and represents a driving mutation. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet (PLT) count. So far, only…
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Keywords:
jak2v617f;
jak2v617f mutation;
essential thrombocytemia;
immune thrombocytopenia ... See more keywords
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Published in 2018 at "Leukemia"
DOI: 10.1038/s41375-018-0295-6
Abstract: Pegylated interferon-α (peg-IFNa) treatment induces molecular responses (MR) in patients with myeloproliferative neoplasms (MPNs), including partial MR (PMR) in 30–40% of patients. Here, we compared the efficacy of IFNa treatment in JAK2V617F- vs. calreticulin (CALR)-mutated…
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Keywords:
jak2v617f;
jak1 stat1;
molecular responses;
calr mutated ... See more keywords
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Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46163-2
Abstract: JAK2/STAT signaling participates in the Ph-negative myeloproliferative neoplasms (MPN) pathophysiology and has been targeted by ruxolitinib, a JAK1/2 inhibitor. In the present study, the impact of ruxolitinib treatment on cytoskeleton-related genes expression was explored. In…
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Keywords:
jak2v617f;
set2 cells;
reversine;
expression ... See more keywords
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1
Published in 2022 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0042-1743470
Abstract: The objective of this study was to assess the risk of arterial thrombosis in patients who harbor the JAK2V617F allele burden ≥1% detected during workup for myeloproliferative neoplasms (MPNs). We conducted a large cross-sectional analysis…
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Keywords:
jak2v617f;
tia stroke;
age;
risk factor ... See more keywords
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0
Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2150984
Abstract: Abstract Myeloproliferative neoplasms are hematological disorders characterized by increased production in one or more myeloid cell lines, associated with driver mutations in JAK2-, MPL- and CALR-genes. The aims of this study were to investigate the…
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Keywords:
calr;
jak2v617f;
patient cohort;
driver mutations ... See more keywords
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2
Published in 2023 at "British Journal of Haematology"
DOI: 10.1111/bjh.18669
Abstract: JAK2V617F is the most frequent mutation in BCR‐ABL‐negative myeloproliferative neoplasms (MPNs). It is an important but not the only determinant of MPN phenotype. We performed high‐throughput sequencing on JAK2V617F+ essential thrombocythaemia (ET) and polycythaemia vera…
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Keywords:
jak2v617f;
wnt catenin;
analysis;
phenotypic heterogeneity ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-110916
Abstract: Introduction Myelofibrosis (MF) occurrence can be attributed to various pathogenic mechanisms. A recent study showed that the neoplastic clone of fibrocytes (spindle shaped, fibroblast-like blood cells derived from monocyte lineage) was essential in primary MF…
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Keywords:
cd16;
jak2v617f;
mpn patients;
research funding ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131432
Abstract: Introduction: JAK2V617F-positive myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell (HSC) disorders characterized by unregulated JAK2/STAT signaling and increased risk of transformation to myelofibrosis (MF). Pathologic JAK2/STAT signaling of the thrombopoietin/thrombopoietin receptor pathway in HSC,…
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Keywords:
jak2v617f;
model;
hmga1;
progression ... See more keywords
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Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139638
Abstract: Increased TGF-β expression in the bone marrow microenvironment is present in most cases of myeloproliferative neoplasms (MPNs), however, its contribution to disease pathogenesis is not well understood. Multiple prior studies show that TGF-β suppresses the…
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Keywords:
jak2v617f;
tgf signaling;
jak2v617f hspcs;
tgf ... See more keywords