TGF-β Signaling Contributes to the Clonal Dominance of Jak2V617F Hematopoietic Stem/Progenitor Cells
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DOI: 10.1182/blood-2020-139638
Abstract: Increased TGF-β expression in the bone marrow microenvironment is present in most cases of myeloproliferative neoplasms (MPNs), however, its contribution to disease pathogenesis is not well understood. Multiple prior studies show that TGF-β suppresses the… read more here.
Keywords: jak2v617f; tgf signaling; jak2v617f hspcs; tgf ... See more keywords