Abnormal Distribution and Function of NK Cells Subsets May Lead to Impaired Tumor Surveillance in a JAK2V617F Myeloproliferative Neoplasm Model
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DOI: 10.1182/blood-2018-99-115006
Abstract: Background: The JAK2V617F mutation is the most common molecular abnormality present in Philadelphia chromosome-negative Classical Myeloproliferative Neoplasms (Ph-neg MPNs), present in approximately 95% of patients with Polycythemia Vera and in almost 50% of patients with… read more here.
Keywords: jak2vf; cd11b; function; cd27 cd11b ... See more keywords
Characteristics and Consequences of Platelets Derived from JAK2-Mutated Megakaryocytes
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DOI: 10.1182/blood-2024-193710
Abstract: A myeloproliferative neoplasm (MPN) with the JAK2-V617F mutation frequently presents with thrombosis. Although blood cell proliferation is one cause of thrombotic events, individuals with JAK2-V617F clonal hematopoiesis and near-normal blood counts are also at higher… read more here.
Keywords: mice; jak2vf plts; jak2vf; podxl ... See more keywords