Partial trisomy 21 contributes to T-cell malignancies induced by JAK3-activating mutations in murine models.
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DOI: 10.1182/bloodadvances.2018016089
Abstract: JAK3-activating mutations are commonly seen in chronic or acute hematologic malignancies affecting the myeloid, megakaryocytic, lymphoid, and natural killer (NK) cell compartment. Overexpression models of mutant JAK3 or pharmacologic inhibition of its kinase activity have… read more here.
Keywords: jak3; jak3 activating; partial trisomy; activating mutations ... See more keywords