Novel CTRP8-RXFP1-JAK3-STAT3 axis promotes Cdc42-dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.12981
Abstract: CTRP8 is the least studied member of the C1Q-TNF related peptide family. We identified CTRP8 as a ligand of the G protein coupled receptor RXFP1 in glioblastoma multiforme (GBM). The CTRP8-RXFP1 ligand-receptor system protects human… read more here.
Keywords: rxfp1; stat3; rxfp1 jak3; jak3 stat3 ... See more keywords
Prevention of DMBA-induced mammary gland tumors in mice by a dual-function inhibitor of JAK3 and EGF receptor tyrosine kinases
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2020.1737014
Abstract: ABSTRACT Objectives: We tested the chemopreventive effect of WHI-P131 in side by side evaluation with the standard anti-breast cancer drug paclitaxel in the well-established 7,12‐dimethylbenz(a)anthracene (DMBA)-induced breast cancer model. Methods: One hundred BALB/cmice were divided… read more here.
Keywords: dmba induced; breast cancer; whi p131; dmba ... See more keywords
P070/O09 miR-221-3p is upregulated in rheumatoid arthritis and affects JAK3/STAT3 signaling in M2-macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2019.59
Abstract: Career situation of first and presenting author Post-doctoral fellow. Introduction Recurrent activation of synovial macrophages is considered as intrinsic factor that precedes rheumatoid arthritis (RA)-related autonomous cytokine cascades. microRNAs (miRs) and Toll-like receptors (TLRs) play… read more here.
Keywords: mir 221; expression; jak3 stat3; inflammatory response ... See more keywords
Mesenchymal stem cells cause induction of granulocyte differentiation of rat bone marrow C-kit+ hematopoietic stem cells through JAK3/STAT3, ERK, and PI3K signaling pathways
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.66737.14633
Abstract: Objective(s): Hematopoietic stem cells (HSCs) are the cells that give rise to different types of blood cells during the hematopoiesis process. Mesenchymal stromal cells (MSCs) as key elements in the bone marrow (BM) niche interact… read more here.
Keywords: jak3 stat3; kit hscs; stat3 erk; stem ... See more keywords