Computational modelling and invitro evaluation identified natural product - Z218 as a novel Janus Kinase-2 (JAK2) inhibitor to combat Beta Thalassemia.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2459
Abstract: Aberrant activity of Janus kinase 2 (JAK2) is a known driver of several myeloproliferative disorders, including polycythemia Vera, and Thalassemia. Several inhibitors have been proposed to inhibit JAK2 activity in order to control the disease… read more here.
Keywords: kinase jak2; kinase; jak2; natural product ... See more keywords
Reversible effects on female rat fertility with abrocitinib, a Janus kinase 1 inhibitor
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DOI: 10.1002/bdr2.2345
Abstract: Abrocitinib is a Janus kinase (JAK) 1 selective inhibitor approved for the treatment of atopic dermatitis. Female reproductive tissues were unaffected in general toxicity studies, but an initial female rat fertility study resulted in adverse… read more here.
Keywords: fertility; rat fertility; janus kinase; abrocitinib janus ... See more keywords
Chrysophanol attenuated isoproterenol‐induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway
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DOI: 10.1002/cbin.11146
Abstract: Cardiac hypertrophy is a common pathological change found in various cardiovascular diseases. Although it has long been recognized as an important risk factor responsible for heart failure, there is still a lack of effective treatments… read more here.
Keywords: cardiac hypertrophy; transcription; induced cardiac; hypertrophy ... See more keywords
Janus kinase 2 variants associated with the transformation of myeloproliferative neoplasms into acute myeloid leukemia
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DOI: 10.1002/cncr.31986
Abstract: Canonical Janus kinase 2 (JAK2) V617F and exon 12 mutations in myeloid neoplasms are well described. There are limited reports of other JAK2 variants of potential clinical relevance. This study was designed to survey JAK2… read more here.
Keywords: myeloproliferative neoplasms; myeloid leukemia; janus kinase; acute myeloid ... See more keywords
Janus kinase signaling as risk factor and therapeutic target for severe SARS‐CoV‐2 infection
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149173
Abstract: Cytokine signaling, especially interferon (IFN) signaling is closely linked to several aspects of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. During initial SARS‐CoV‐2 infection, symptomatic patients present with impaired type I/III IFN‐mediated antiviral responses.… read more here.
Keywords: sars cov; jak; cov infection; janus kinase ... See more keywords
Janus Kinase Inhibitors and Non-Melanoma Skin Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-020-00815-y
Abstract: JAK (janus kinase) inhibitors are becoming increasingly prescribed for various conditions from dermatologic diseases to graft versus host disease in bone marrow transplant recipients. This class of drugs has been found to be truly life-changing… read more here.
Keywords: kinase inhibitors; non melanoma; skin; skin cancer ... See more keywords
Evaluating Current and Emergent JAK Inhibitors for Alopecia Areata: A Narrative Review
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DOI: 10.1007/s13555-025-01517-9
Abstract: Alopecia areata (AA) is an autoimmune condition characterized by non-scarring hair loss on the scalp, face, and body, affecting approximately 2% of the global population. Current treatments, including topical corticosteroids, topical immunotherapies, and systemic immunosuppressants,… read more here.
Keywords: janus kinase; dermatology; hair; alopecia areata ... See more keywords
The Burden of Alopecia Areata and Management with Baricitinib in the United Arab Emirates: A Narrative Review
Sign Up to like & getrecommendations! Published in 2025 at "Dermatology and Therapy"
DOI: 10.1007/s13555-025-01546-4
Abstract: Alopecia areata is an inflammatory autoimmune disease that presents as non-scarring hair loss in adults and children and causes substantial psychological distress, economic burden, and reduced quality of life for those affected. Although steroids and… read more here.
Keywords: treatment; janus kinase; alopecia areata; burden ... See more keywords
Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2021 at "Infection"
DOI: 10.1007/s15010-021-01730-6
Abstract: The Coronavirus disease 2019 (COVID-19) pandemic is one of the most devastating global problems. Regarding the lack of disease-specific treatments, repurposing drug therapy is currently considered a promising therapeutic approach in pandemic situations. Recently, the… read more here.
Keywords: combination therapy; baricitinib; therapy; infection ... See more keywords
Critical Assessment of Pharmacokinetic Drug–Drug Interaction Potential of Tofacitinib, Baricitinib and Upadacitinib, the Three Approved Janus Kinase Inhibitors for Rheumatoid Arthritis Treatment
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DOI: 10.1007/s40264-020-00938-z
Abstract: The introduction of novel, small-molecule Janus kinase inhibitors namely tofacitinib, baricitinib and upadacitinib has provided an alternative treatment option for patients with rheumatoid arthritis outside of traditional drugs and expensive biologics. This review aimed to… read more here.
Keywords: baricitinib; tofacitinib baricitinib; drug; baricitinib upadacitinib ... See more keywords
Biologics or Janus Kinase Inhibitors in Rheumatoid Arthritis Patients Who are Insufficient Responders to Conventional Anti-Rheumatic Drugs
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DOI: 10.1007/s40265-024-02059-8
Abstract: Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease which can induce progressive disability if not properly treated early. Over the last 20 years, the improvement of knowledge on the pathogenesis of the disease has… read more here.
Keywords: kinase inhibitors; choice; rheumatoid arthritis; janus kinase ... See more keywords