Janus kinases inhibitors for treating patients with rhupus.
Sign Up to like & getrecommendations! Published in 2020 at "Joint bone spine"
DOI: 10.1016/j.jbspin.2020.05.010
Abstract: HIGHLIGHTS • baricitinib and tofacitinib are effective in patients with Rhupus • JAK inhibitors are an alternative option in patients with refractory SLE • JAK inhibitors have a steroid-sparing effect in patients with Rhupus read more here.
Keywords: inhibitors treating; patients rhupus; kinases inhibitors; treating patients ... See more keywords
Pharmacophore-Based Virtual Screening and Experimental Validation of Pyrazolone-Derived Inhibitors toward Janus Kinases
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04535
Abstract: Janus kinases (JAKs) are nonreceptor protein tyrosine kinases that play a role in a broad range of cell signaling. JAK2 and JAK3 have been involved in the pathogenesis of common lymphoid-derived diseases and leukemia cancer.… read more here.
Keywords: pharmacophore based; virtual screening; janus kinases; jak2 ... See more keywords
Inhibitors of the Janus Kinases: A New Oral Treatment Option for Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Gastroenterology"
DOI: 10.1097/mcg.0000000000001404
Abstract: To the Editor: As the Medical Strategy Head Gastroenterology and Global Medical Lead for Xeljanz ulcerative colitis (UC), Inflammation and Immunology Medical Affairs, at Pfizer Inc., I read with great interest the article by Antonelli… read more here.
Keywords: gastroenterology; ulcerative colitis; janus kinases; inhibitors janus ... See more keywords
Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
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DOI: 10.1182/blood.2020006846
Abstract: CRLF2-rearranged (CRLF2r) acute lymphoblastic leukemia (ALL) comprises over half of Philadelphia chromosome-like (Ph-like) ALL, is associated with poor outcome in children and adults. Overexpression of CRLF2 results in activation of JAK-STAT and parallel signaling pathways… read more here.
Keywords: degradation; jak; crlf2 rearranged; leukemia ... See more keywords
In Silico and In Vitro Study of Janus Kinases Inhibitors from Naphthoquinones
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020597
Abstract: Janus kinases (JAKs) are involved in numerous cellular signaling processes related to immune cell functions. JAK2 and JAK3 are associated with the pathogenesis of leukemia and common lymphoid-derived illnesses. JAK2/3 inhibitors could reduce the risk… read more here.
Keywords: silico vitro; study janus; kinases inhibitors; janus kinases ... See more keywords