A Phase 1, Randomized, Placebo‐Controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Subcutaneous Tezepelumab in Healthy Japanese Men
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.775
Abstract: Tezepelumab, a human immunoglobulin G2 monoclonal antibody against thymic stromal lymphopoietin, is currently under clinical development for the treatment of severe, uncontrolled asthma. This phase 1, randomized, placebo‐controlled, single‐ascending‐dose study assessed the safety, tolerability, pharmacokinetics,… read more here.
Keywords: placebo; safety; phase randomized; healthy japanese ... See more keywords
Association of equol producing status with aortic calcification in middle-aged Japanese men: The ERA JUMP study.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2022.01.065
Abstract: BACKGROUND Equol, an isoflavone (ISF)-derived metabolite by the gut microbiome in certain individuals termed as equol-producers, might be the key anti-atherogenic component of ISFs. Our objective was to determine the association between equol-producing status and… read more here.
Keywords: japanese men; producing status; equol producers; association ... See more keywords
Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Nutrition"
DOI: 10.1017/s000711451600458x
Abstract: Abstract Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary… read more here.
Keywords: cac; association; equol producers; japanese men ... See more keywords
Enzalutamide with androgen deprivation therapy in Japanese men with metastatic hormone‐sensitive prostate cancer: A subgroup analysis of the phase III ARCHES study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Urology"
DOI: 10.1111/iju.14568
Abstract: To evaluate the efficacy and safety of enzalutamide plus androgen deprivation therapy in Japanese men with metastatic hormone‐sensitive prostate cancer. read more here.
Keywords: men metastatic; deprivation therapy; metastatic hormone; androgen deprivation ... See more keywords
Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men
Sign Up to like & getrecommendations! Published in 2022 at "Cerebrovascular Diseases"
DOI: 10.1159/000524243
Abstract: Background: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions… read more here.
Keywords: serum; cerebrovascular lesions; fatty acids; association ... See more keywords
Intracranial Artery Stenosis and Its Association With Conventional Risk Factors in a General Population of Japanese Men.
Sign Up to like & getrecommendations! Published in 2019 at "Stroke"
DOI: 10.1161/strokeaha.119.025964
Abstract: Background and Purpose- Few community-based studies have reported the prevalence of intracranial artery stenosis (ICAS) assessed with magnetic resonance angiography. The aim was to determine the prevalence of ICAS using magnetic resonance angiography in a… read more here.
Keywords: population; japanese men; intracranial artery; risk ... See more keywords
Soy Intake and Risk of Type 2 Diabetes Among Japanese Men and Women: JACC Study
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2021.813742
Abstract: The evidence on the protective effects of soy foods against type 2 diabetes has been inconsistent. We thought to examine the association between the dietary intakes of soy and the risk of diabetes in a… read more here.
Keywords: risk type; risk; type diabetes; japanese men ... See more keywords
Relationship between Serum Irisin Levels and MRI-Measured Cerebral Small Vessel Disease in Japanese Men.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of atherosclerosis and thrombosis"
DOI: 10.5551/jat.63824
Abstract: AIM Irisin, an exercise-induced myokine, is a potential neurotrophic factor; however, its relationship with cerebral small vessel disease (CSVD) remains unknown. Therefore, we investigated whether serum irisin levels are associated with CSVD in healthy Japanese… read more here.
Keywords: serum irisin; csvd; total csvd; irisin levels ... See more keywords