Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection
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DOI: 10.1007/s00436-017-5441-y
Abstract: Highly effective and safe prophylactic vaccines are urgently needed to sustainably control schistosomiasis, one of the most serious endemic zoonoses in China. In this study, we characterized adenylate kinase 1 from Schistosoma japonicum (SjAK1), a… read more here.
Keywords: schistosoma japonicum; adenylate kinase; schistosoma; japonicum infection ... See more keywords
Immune modulation of Th1, Th2, and T-reg transcriptional factors differing from cytokine levels in Schistosoma japonicum infection
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DOI: 10.1007/s00436-017-5678-5
Abstract: In spite of long-term integrated control programs for Schistosoma japonicum infection in China, the infection is still persistent due to its zoonotic transmission and disease severity which further complicate its control. Th1, Th2, and T-reg… read more here.
Keywords: schistosoma japonicum; infection; th1 th2; japonicum infection ... See more keywords
Mechanism by which the combination of SjCL3 and SjGAPDH protects against Schistosoma japonicum infection
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DOI: 10.1007/s00436-020-06916-9
Abstract: A vaccine is an important method to control schistosomiasis. Molecules related to lung-stage schistosomulum are considered potential vaccine candidates. We previously showed that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and cathepsin L3 (CL3) displayed differential expression in the… read more here.
Keywords: combination; schistosoma japonicum; japonicum infection; cl3 ... See more keywords
Changes in microRNA expression in response to Schistosoma japonicum infection
Sign Up to like & getrecommendations! Published in 2017 at "Parasite Immunology"
DOI: 10.1111/pim.12416
Abstract: Schistosomiasis japonicum is one of the most serious zoonotic diseases in the world. There is increasing evidence to show that host miRNAs are modulated following Schistosoma japonicum infection, and some of these miRNAs may play… read more here.
Keywords: schistosoma japonicum; japonicum infection; infection; response ... See more keywords
TLR3 Modulates the Response of NK Cells against Schistosoma japonicum
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/7519856
Abstract: Natural killer (NK) cells are classic innate immune cells that play roles in many types of infectious diseases. NK cells possess many kinds of TLRs that allow them to sense and respond to invading pathogens.… read more here.
Keywords: response; schistosoma japonicum; tlr3; tlr3 modulates ... See more keywords
iNOS is essential to maintain a protective Th1/Th2 response and the production of cytokines/chemokines against Schistosoma japonicum infection in rats
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0010403
Abstract: Humans and a wide range of mammals are generally susceptible to Schistosoma infection, while some rodents such as Rattus rats and Microtus spp are not. We previously demonstrated that inherent high expression levels of nitric… read more here.
Keywords: infection rats; inos rats; th1; infection ... See more keywords
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum
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DOI: 10.1371/journal.pntd.0010851
Abstract: Toll-like receptors (TLRs) play an important role in the induction of innate and adaptive immune responses against Schistosoma japonicum (S. japonicum) infection. However, the role of Toll-like receptor 7 (TLR7) in the mouse lung during… read more here.
Keywords: tlr7; infection; lung; japonicum ... See more keywords
Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation
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DOI: 10.3389/fcell.2021.678377
Abstract: Schistosoma japonicum infection showed protective effects against allergic airway inflammation (AAI). However, controversial findings exist especially regarding the timing of the helminth infection and the underlying mechanisms. Most previous studies focused on understanding the preventive… read more here.
Keywords: lung stage; japonicum infection; infection;
Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection
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DOI: 10.3389/fimmu.2022.911139
Abstract: Schistosomes undergo complicated migration in final hosts during infection, associated with differential immune responses. It has been shown that CD4+ T cells play critical roles in response to Schistosoma infections and accumulated documents have indicated… read more here.
Keywords: cell; host cells; infection; japonicum infection ... See more keywords
Longitudinal Immune Profiling Highlights CD4+ T Cell Exhaustion Correlated with Liver Fibrosis in Schistosoma japonicum Infection.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of immunology"
DOI: 10.4049/jimmunol.2200301
Abstract: Schistosomiasis remains an important public health concern. The eggs deposited in livers invoke a Th2-dominant response, which mediates the fibrotic granulomatous response. However, the mechanisms involved in this immunopathological process are still not perfectly clear.… read more here.
Keywords: cd4; cd4 cells; infection; exhausted cd4 ... See more keywords